Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children

The increasing scientific information clearly demonstrates the important role of inflammation in asthma. This evidence has led physicians to focus their treatment on the elimination of inflammation instead of working solely against bronchoconstriction. Steroids and nonsteroidal agents are currently...

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Main Author: Pierre Gaudreault
Format: Article
Language:English
Published: Wiley 1995-01-01
Series:Canadian Respiratory Journal
Online Access:http://dx.doi.org/10.1155/1995/956715
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author Pierre Gaudreault
author_facet Pierre Gaudreault
author_sort Pierre Gaudreault
collection DOAJ
description The increasing scientific information clearly demonstrates the important role of inflammation in asthma. This evidence has led physicians to focus their treatment on the elimination of inflammation instead of working solely against bronchoconstriction. Steroids and nonsteroidal agents are currently used to prevent this inflammatory component. This paper focuses only on nonstcroidal anti-inflammatory agents such as sodium cromoglycate, nedocromil sodium and ketotifen and their use in pediatric asthma. The discussion on each medication addresses its mechanism of action, the evidence concerning its efficacy in pediatrics (ie, clinical pharmacology, acute bronchial challenge, late asthmatic response, bronchial hyperrcactivity, clinical efficacy) and the pediatric dose.
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spelling doaj-art-0754ee4562174cc8862e841baf196a0c2025-02-03T05:53:16ZengWileyCanadian Respiratory Journal1198-22411995-01-012Suppl A24A31A10.1155/1995/956715Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in ChildrenPierre Gaudreault0Department of Pediatrics, University of Montreal, and Clinical Pharmacology and Toxicology Section and Emergency Medicine Service, Hôpital Sainte-Justine, Montréal, Québec, CanadaThe increasing scientific information clearly demonstrates the important role of inflammation in asthma. This evidence has led physicians to focus their treatment on the elimination of inflammation instead of working solely against bronchoconstriction. Steroids and nonsteroidal agents are currently used to prevent this inflammatory component. This paper focuses only on nonstcroidal anti-inflammatory agents such as sodium cromoglycate, nedocromil sodium and ketotifen and their use in pediatric asthma. The discussion on each medication addresses its mechanism of action, the evidence concerning its efficacy in pediatrics (ie, clinical pharmacology, acute bronchial challenge, late asthmatic response, bronchial hyperrcactivity, clinical efficacy) and the pediatric dose.http://dx.doi.org/10.1155/1995/956715
spellingShingle Pierre Gaudreault
Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children
Canadian Respiratory Journal
title Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children
title_full Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children
title_fullStr Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children
title_full_unstemmed Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children
title_short Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children
title_sort nonsteroidal anti inflammatory agents in the treatment of asthma in children
url http://dx.doi.org/10.1155/1995/956715
work_keys_str_mv AT pierregaudreault nonsteroidalantiinflammatoryagentsinthetreatmentofasthmainchildren