Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiv...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/846750 |
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| author | Hye-Sook Chang Daiji Endoh Yushi Ishida Hiroyuki Takahashi Shuji Ozawa Masanobu Hayashi Akira Yabuki Osamu Yamato |
| author_facet | Hye-Sook Chang Daiji Endoh Yushi Ishida Hiroyuki Takahashi Shuji Ozawa Masanobu Hayashi Akira Yabuki Osamu Yamato |
| author_sort | Hye-Sook Chang |
| collection | DOAJ |
| description | To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation. Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage. X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds. The protective effect was more potent with 2PTS than NPTS. Onions and garlic have antiradiation potential. |
| format | Article |
| id | doaj-art-073f85a99d77444d9a6628f99024d680 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-073f85a99d77444d9a6628f99024d6802025-02-03T01:21:29ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/846750846750Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and GarlicHye-Sook Chang0Daiji Endoh1Yushi Ishida2Hiroyuki Takahashi3Shuji Ozawa4Masanobu Hayashi5Akira Yabuki6Osamu Yamato7Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, JapanDepartment of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Hokkaido 069-8501, Ebetsu, JapanDepartment of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Hokkaido 069-8501, Ebetsu, JapanInformation Systems Department, Industrial Research Institute, Hokkaido Research Organization, Kita-19 Nishi-11, Hokkaido 060-0819, Sapporo, JapanLaboratory of Natural Products Chemistry, Department of Sustainable Agriculture, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Hokkaido 069-8501, Ebetsu, JapanDepartment of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Hokkaido 069-8501, Ebetsu, JapanLaboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, JapanLaboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, JapanTo evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation. Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage. X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds. The protective effect was more potent with 2PTS than NPTS. Onions and garlic have antiradiation potential.http://dx.doi.org/10.1100/2012/846750 |
| spellingShingle | Hye-Sook Chang Daiji Endoh Yushi Ishida Hiroyuki Takahashi Shuji Ozawa Masanobu Hayashi Akira Yabuki Osamu Yamato Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic The Scientific World Journal |
| title | Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic |
| title_full | Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic |
| title_fullStr | Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic |
| title_full_unstemmed | Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic |
| title_short | Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic |
| title_sort | radioprotective effect of alk en yl thiosulfates derived from allium vegetables against dna damage caused by x ray irradiation in cultured cells antiradiation potential of onions and garlic |
| url | http://dx.doi.org/10.1100/2012/846750 |
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