The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer
ObjectiveTo investigate the association between the interval from biopsy to radical prostatectomy (RP) and biochemical recurrence (BCR) in prostate cancer patients.MethodsWithin a tertiary-care database (01/2014 to 06/2023), D’Amico intermediate- and high-risk prostate cancer patients were stratifie...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1533800/full |
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| author | Carolin Siech Mike Wenzel Georgina Knoblich Cristina Cano Garcia Clara Humke Felix Preisser Miriam Traumann Luis A. Kluth Felix K. H. Chun Philipp Mandel Philipp Mandel |
| author_facet | Carolin Siech Mike Wenzel Georgina Knoblich Cristina Cano Garcia Clara Humke Felix Preisser Miriam Traumann Luis A. Kluth Felix K. H. Chun Philipp Mandel Philipp Mandel |
| author_sort | Carolin Siech |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between the interval from biopsy to radical prostatectomy (RP) and biochemical recurrence (BCR) in prostate cancer patients.MethodsWithin a tertiary-care database (01/2014 to 06/2023), D’Amico intermediate- and high-risk prostate cancer patients were stratified according to interval from biopsy to RP (≤3 vs. >3-≤6 months). Kaplan-Meier survival analyses and Cox regression models addressed BCR.ResultsOf 680 patients, 328 vs. 153 exhibited intermediate-risk prostate cancer and had interval from biopsy to RP ≤3 vs. >3-≤6 months. Similarly, 158 vs. 41 exhibited high-risk prostate cancer and had interval from biopsy to RP ≤3 vs. >3-≤6 months. Median interval from biopsy to RP was 59 vs. 113 days in intermediate- and 55 vs. 117 days in high-risk patients, respectively. In both intermediate- and high-risk patients, rates of adverse histopathological outcomes, namely pT3/pT4, pN1, and R1 status, did not differ according to interval from biopsy to RP. In survival analyses, three-year BCR-free survival rates were 82 vs. 88% in intermediate-risk (p=0.5) and 76 vs. 75% in high-risk patients (p=1). In multivariable Cox regression models, BCR did not significantly differ according to interval from biopsy to RP in intermediate- (hazard ratio 0.85, 95% confidence interval 0.49-1.46; p=0.5) and high-risk patients (hazard ratio 1.05, 95% confidence interval 0.50-2.22; p=0.9).ConclusionsBoth intermediate- and high-risk prostate cancer patients with an interval from biopsy to RP >3-≤6 months did not differ from those treated with RP ≤3 months after biopsy, regarding adverse histopathological outcomes and BCR rates. Therefore, it might be safe to postpone RP up to six months. |
| format | Article |
| id | doaj-art-0738c03df38740aca0bac92f932b68dd |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-0738c03df38740aca0bac92f932b68dd2025-02-04T05:28:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011410.3389/fonc.2024.15338001533800The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancerCarolin Siech0Mike Wenzel1Georgina Knoblich2Cristina Cano Garcia3Clara Humke4Felix Preisser5Miriam Traumann6Luis A. Kluth7Felix K. H. Chun8Philipp Mandel9Philipp Mandel10Goethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyMartini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyGoethe University Frankfurt, University Hospital, Department of Urology, Frankfurt am Main, GermanyMartini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, GermanyObjectiveTo investigate the association between the interval from biopsy to radical prostatectomy (RP) and biochemical recurrence (BCR) in prostate cancer patients.MethodsWithin a tertiary-care database (01/2014 to 06/2023), D’Amico intermediate- and high-risk prostate cancer patients were stratified according to interval from biopsy to RP (≤3 vs. >3-≤6 months). Kaplan-Meier survival analyses and Cox regression models addressed BCR.ResultsOf 680 patients, 328 vs. 153 exhibited intermediate-risk prostate cancer and had interval from biopsy to RP ≤3 vs. >3-≤6 months. Similarly, 158 vs. 41 exhibited high-risk prostate cancer and had interval from biopsy to RP ≤3 vs. >3-≤6 months. Median interval from biopsy to RP was 59 vs. 113 days in intermediate- and 55 vs. 117 days in high-risk patients, respectively. In both intermediate- and high-risk patients, rates of adverse histopathological outcomes, namely pT3/pT4, pN1, and R1 status, did not differ according to interval from biopsy to RP. In survival analyses, three-year BCR-free survival rates were 82 vs. 88% in intermediate-risk (p=0.5) and 76 vs. 75% in high-risk patients (p=1). In multivariable Cox regression models, BCR did not significantly differ according to interval from biopsy to RP in intermediate- (hazard ratio 0.85, 95% confidence interval 0.49-1.46; p=0.5) and high-risk patients (hazard ratio 1.05, 95% confidence interval 0.50-2.22; p=0.9).ConclusionsBoth intermediate- and high-risk prostate cancer patients with an interval from biopsy to RP >3-≤6 months did not differ from those treated with RP ≤3 months after biopsy, regarding adverse histopathological outcomes and BCR rates. Therefore, it might be safe to postpone RP up to six months.https://www.frontiersin.org/articles/10.3389/fonc.2024.1533800/fullBCRprostate cancerprostate biopsyradical prostatectomytime to event |
| spellingShingle | Carolin Siech Mike Wenzel Georgina Knoblich Cristina Cano Garcia Clara Humke Felix Preisser Miriam Traumann Luis A. Kluth Felix K. H. Chun Philipp Mandel Philipp Mandel The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer Frontiers in Oncology BCR prostate cancer prostate biopsy radical prostatectomy time to event |
| title | The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer |
| title_full | The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer |
| title_fullStr | The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer |
| title_full_unstemmed | The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer |
| title_short | The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer |
| title_sort | association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate and high risk prostate cancer |
| topic | BCR prostate cancer prostate biopsy radical prostatectomy time to event |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1533800/full |
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