Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin
Curcumin, as a natural phenolic substance, is extracted from the rhizome of Curcuma longa (turmeric), which is effective in bone healthfulness. Calcitriol is an effective hormone in regulating bone remodeling and mineral homeostasis and immune response. Mesenchymal stem cells (MSCs) are found in mos...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/9980137 |
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| author | Mohammad Samiei Atefeh Abedi Simin Sharifi Solmaz Maleki Dizaj |
| author_facet | Mohammad Samiei Atefeh Abedi Simin Sharifi Solmaz Maleki Dizaj |
| author_sort | Mohammad Samiei |
| collection | DOAJ |
| description | Curcumin, as a natural phenolic substance, is extracted from the rhizome of Curcuma longa (turmeric), which is effective in bone healthfulness. Calcitriol is an effective hormone in regulating bone remodeling and mineral homeostasis and immune response. Mesenchymal stem cells (MSCs) are found in most dental tissues and resemble bone marrow-derived MSCs. In this work, we investigated the effect of combination and individual treatment of curcumin and calcitriol on early osteogenic differentiation of dental pulp stem cells (DPSCs). Early osteogenic differentiation was evaluated and confirmed by the gene expression level of ALP and its activity. Curcumin individually and in combination with calcitriol increased ALP activity and osteoblast-specific mRNA expression of ALP when DPSCs were cultured in an osteogenic medium. Calcitriol alone increased the enzyme more than in combination with curcumin. These findings demonstrate that curcumin can induce early osteogenic differentiation of DPSCs like calcitriol as a potent stimulant of osteogenesis. |
| format | Article |
| id | doaj-art-0718a683b85742729ff21d3c3f93e2af |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0718a683b85742729ff21d3c3f93e2af2025-02-03T01:04:27ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/99801379980137Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and CurcuminMohammad Samiei0Atefeh Abedi1Simin Sharifi2Solmaz Maleki Dizaj3Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, IranDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranCurcumin, as a natural phenolic substance, is extracted from the rhizome of Curcuma longa (turmeric), which is effective in bone healthfulness. Calcitriol is an effective hormone in regulating bone remodeling and mineral homeostasis and immune response. Mesenchymal stem cells (MSCs) are found in most dental tissues and resemble bone marrow-derived MSCs. In this work, we investigated the effect of combination and individual treatment of curcumin and calcitriol on early osteogenic differentiation of dental pulp stem cells (DPSCs). Early osteogenic differentiation was evaluated and confirmed by the gene expression level of ALP and its activity. Curcumin individually and in combination with calcitriol increased ALP activity and osteoblast-specific mRNA expression of ALP when DPSCs were cultured in an osteogenic medium. Calcitriol alone increased the enzyme more than in combination with curcumin. These findings demonstrate that curcumin can induce early osteogenic differentiation of DPSCs like calcitriol as a potent stimulant of osteogenesis.http://dx.doi.org/10.1155/2021/9980137 |
| spellingShingle | Mohammad Samiei Atefeh Abedi Simin Sharifi Solmaz Maleki Dizaj Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin Stem Cells International |
| title | Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin |
| title_full | Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin |
| title_fullStr | Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin |
| title_full_unstemmed | Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin |
| title_short | Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin |
| title_sort | early osteogenic differentiation stimulation of dental pulp stem cells by calcitriol and curcumin |
| url | http://dx.doi.org/10.1155/2021/9980137 |
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