The Role of GABAergic Inhibition in Ocular Dominance Plasticity
During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disord...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/391763 |
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| author | J. Alexander Heimel Daniëlle van Versendaal Christiaan N. Levelt |
| author_facet | J. Alexander Heimel Daniëlle van Versendaal Christiaan N. Levelt |
| author_sort | J. Alexander Heimel |
| collection | DOAJ |
| description | During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disorders caused by defective synaptic plasticity. One of the central mechanisms responsible for opening the sensitive period is the maturation of inhibitory innervation. Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation. The mechanisms through which the development of inhibitory innervation triggers and potentially closes the sensitive period may involve plasticity of inhibitory inputs or permissive regulation of excitatory synapse plasticity. Here, we discuss the current state of knowledge in the field and open questions to be addressed. |
| format | Article |
| id | doaj-art-07175fba5b8243eca5b4e629f00bb7f1 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-07175fba5b8243eca5b4e629f00bb7f12025-02-03T01:31:35ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/391763391763The Role of GABAergic Inhibition in Ocular Dominance PlasticityJ. Alexander Heimel0Daniëlle van Versendaal1Christiaan N. Levelt2Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The NetherlandsDepartment of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The NetherlandsDepartment of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The NetherlandsDuring the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disorders caused by defective synaptic plasticity. One of the central mechanisms responsible for opening the sensitive period is the maturation of inhibitory innervation. Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation. The mechanisms through which the development of inhibitory innervation triggers and potentially closes the sensitive period may involve plasticity of inhibitory inputs or permissive regulation of excitatory synapse plasticity. Here, we discuss the current state of knowledge in the field and open questions to be addressed.http://dx.doi.org/10.1155/2011/391763 |
| spellingShingle | J. Alexander Heimel Daniëlle van Versendaal Christiaan N. Levelt The Role of GABAergic Inhibition in Ocular Dominance Plasticity Neural Plasticity |
| title | The Role of GABAergic Inhibition in Ocular Dominance Plasticity |
| title_full | The Role of GABAergic Inhibition in Ocular Dominance Plasticity |
| title_fullStr | The Role of GABAergic Inhibition in Ocular Dominance Plasticity |
| title_full_unstemmed | The Role of GABAergic Inhibition in Ocular Dominance Plasticity |
| title_short | The Role of GABAergic Inhibition in Ocular Dominance Plasticity |
| title_sort | role of gabaergic inhibition in ocular dominance plasticity |
| url | http://dx.doi.org/10.1155/2011/391763 |
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