Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress
Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of for...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0018 |
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| author | Juškaitė Vaida Ramanauskienė Kristina Briedis Vitalis |
| author_facet | Juškaitė Vaida Ramanauskienė Kristina Briedis Vitalis |
| author_sort | Juškaitė Vaida |
| collection | DOAJ |
| description | Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. In vivo biological testing confirmed the ability of resveratrol to protect cells from oxidative stress and to increase cell viability. It was concluded that microemulsions might be considered in the development of UV light sensitive compounds. |
| format | Article |
| id | doaj-art-07010d8c9a2a492bb7a43ff23aa793f4 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-07010d8c9a2a492bb7a43ff23aa793f42025-02-02T10:06:42ZengSciendoActa Pharmaceutica1846-95582017-06-0167224725610.1515/acph-2017-0018acph-2017-0018Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stressJuškaitė Vaida0Ramanauskienė Kristina1Briedis Vitalis2Lithuanian University of Health Sciences, Department of Clinical Pharmacy, 50161 Kaunas, LithuaniaLithuanian University of Health Sciences, Department of Clinical Pharmacy, 50161 Kaunas, LithuaniaLithuanian University of Health Sciences, Department of Clinical Pharmacy, 50161 Kaunas, LithuaniaResveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. In vivo biological testing confirmed the ability of resveratrol to protect cells from oxidative stress and to increase cell viability. It was concluded that microemulsions might be considered in the development of UV light sensitive compounds.https://doi.org/10.1515/acph-2017-0018microemulsionresveratrolphotostabilityha-cat cellsuvboxidative stress |
| spellingShingle | Juškaitė Vaida Ramanauskienė Kristina Briedis Vitalis Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress Acta Pharmaceutica microemulsion resveratrol photostability ha-cat cells uvb oxidative stress |
| title | Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress |
| title_full | Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress |
| title_fullStr | Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress |
| title_full_unstemmed | Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress |
| title_short | Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress |
| title_sort | testing of resveratrol microemulsion photostability and protective effect against uv induced oxidative stress |
| topic | microemulsion resveratrol photostability ha-cat cells uvb oxidative stress |
| url | https://doi.org/10.1515/acph-2017-0018 |
| work_keys_str_mv | AT juskaitevaida testingofresveratrolmicroemulsionphotostabilityandprotectiveeffectagainstuvinducedoxidativestress AT ramanauskienekristina testingofresveratrolmicroemulsionphotostabilityandprotectiveeffectagainstuvinducedoxidativestress AT briedisvitalis testingofresveratrolmicroemulsionphotostabilityandprotectiveeffectagainstuvinducedoxidativestress |