A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT
Accurate segmentation of large choroidal vessels using optical coherence tomography (OCT) images enables unprecedented quantitative analysis to understand choroidal diseases. In this paper, we propose a novel multi-scale and fine-grained network called MFGNet. Since choroidal vessels are small targe...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1508358/full |
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| author | Wei Huang Qifeng Yan Lei Mou Yitian Zhao Wei Chen Wei Chen Wei Chen |
| author_facet | Wei Huang Qifeng Yan Lei Mou Yitian Zhao Wei Chen Wei Chen Wei Chen |
| author_sort | Wei Huang |
| collection | DOAJ |
| description | Accurate segmentation of large choroidal vessels using optical coherence tomography (OCT) images enables unprecedented quantitative analysis to understand choroidal diseases. In this paper, we propose a novel multi-scale and fine-grained network called MFGNet. Since choroidal vessels are small targets, long-range dependencies need to be considered, therefore, we developed a two-branch fine-grained feature extraction module that can mix the long-range information extracted by TransFormer with the local information extracted by convolution in parallel, introducing information exchange between the two branches. To address the problem of low contrast and blurred boundaries of choroidal vessels in OCT images, we developed a large kernel and multi-scale attention module, which can improve the features of the target area through multi-scale convolution kernels, channel mixing and feature refinement. We quantitatively evaluated the MFGNet on 800 OCT images with large choroidal vessels manually annotated. The experimental results show that the proposed method has the best performance compared to the most advanced segmentation networks currently available. It is noteworthy that the large choroidal vessels were reconstructed in three dimensions (3D) based on the segmentation results and several 3D morphological parameters were calculated. The statistical analysis of these parameters revealed significant differences between the healthy control group and the high myopia group, thereby confirming the value of the proposed work in facilitating subsequent understanding of the disease and clinical decision-making. |
| format | Article |
| id | doaj-art-06e5208e08764678b5ff813bfca7dbfb |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-06e5208e08764678b5ff813bfca7dbfb2025-01-28T06:40:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011310.3389/fcell.2025.15083581508358A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCTWei Huang0Qifeng Yan1Lei Mou2Yitian Zhao3Wei Chen4Wei Chen5Wei Chen6School of Biomedical Engineering, Hainan University, Haikou, ChinaLaboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, ChinaLaboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, ChinaLaboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, ChinaSchool of Biomedical Engineering, Hainan University, Haikou, ChinaNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, ChinaAccurate segmentation of large choroidal vessels using optical coherence tomography (OCT) images enables unprecedented quantitative analysis to understand choroidal diseases. In this paper, we propose a novel multi-scale and fine-grained network called MFGNet. Since choroidal vessels are small targets, long-range dependencies need to be considered, therefore, we developed a two-branch fine-grained feature extraction module that can mix the long-range information extracted by TransFormer with the local information extracted by convolution in parallel, introducing information exchange between the two branches. To address the problem of low contrast and blurred boundaries of choroidal vessels in OCT images, we developed a large kernel and multi-scale attention module, which can improve the features of the target area through multi-scale convolution kernels, channel mixing and feature refinement. We quantitatively evaluated the MFGNet on 800 OCT images with large choroidal vessels manually annotated. The experimental results show that the proposed method has the best performance compared to the most advanced segmentation networks currently available. It is noteworthy that the large choroidal vessels were reconstructed in three dimensions (3D) based on the segmentation results and several 3D morphological parameters were calculated. The statistical analysis of these parameters revealed significant differences between the healthy control group and the high myopia group, thereby confirming the value of the proposed work in facilitating subsequent understanding of the disease and clinical decision-making.https://www.frontiersin.org/articles/10.3389/fcell.2025.1508358/fulloptical coherence tomographychoroidsegmentation algorithm3D reconstructionfeature analysis |
| spellingShingle | Wei Huang Qifeng Yan Lei Mou Yitian Zhao Wei Chen Wei Chen Wei Chen A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT Frontiers in Cell and Developmental Biology optical coherence tomography choroid segmentation algorithm 3D reconstruction feature analysis |
| title | A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT |
| title_full | A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT |
| title_fullStr | A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT |
| title_full_unstemmed | A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT |
| title_short | A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT |
| title_sort | novel multi scale and fine grained network for large choroidal vessels segmentation in oct |
| topic | optical coherence tomography choroid segmentation algorithm 3D reconstruction feature analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1508358/full |
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