Helminth Parasites and the Modulation of Joint Inflammation
There is an urgent need to develop better therapeutics for autoimmune and autoinflammatory diseases, of which musculoskeletal disorders such as rheumatoid arthritis are particularly prevalent and debilitating. Helminth parasites are accomplished masters at modifying their hosts' immune activity...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2011/942616 |
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| _version_ | 1832565072715579392 |
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| author | Chelsea E. Matisz Jason J. McDougall Keith A. Sharkey Derek M. McKay |
| author_facet | Chelsea E. Matisz Jason J. McDougall Keith A. Sharkey Derek M. McKay |
| author_sort | Chelsea E. Matisz |
| collection | DOAJ |
| description | There is an urgent need to develop better therapeutics for autoimmune and autoinflammatory diseases, of which musculoskeletal disorders such as rheumatoid arthritis are particularly prevalent and debilitating. Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. Substantial proof-of-principal data supporting the concept that infection with helminth parasites can reduce the severity of concomitant disease has been amassed from models of mucosal inflammation. Indeed, infection with helminth parasites has been tried as a therapy in inflammatory bowel disease, and there are case reports relating to other conditions (e.g., autism); however, the impact of infection with parasitic helminths on musculoskeletal diseases has not been extensively studied. Here, we present the view that such a strategy should be applied to the amelioration of joint inflammation and review the literature that supports this contention. |
| format | Article |
| id | doaj-art-06dbef9b1e9d4ec382263c82da09ad8c |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-06dbef9b1e9d4ec382263c82da09ad8c2025-02-03T01:09:30ZengWileyJournal of Parasitology Research2090-00232090-00312011-01-01201110.1155/2011/942616942616Helminth Parasites and the Modulation of Joint InflammationChelsea E. Matisz0Jason J. McDougall1Keith A. Sharkey2Derek M. McKay3Gastrointestinal Research Group, Department of Physiology and Pharmacology, The Calvin, Phoebe and Joan Snyder Institute of Infection Immunity and Inflammation, 1877 HSC University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, CanadaInflammation Research Network, Department of Physiology and Pharmacology, The Calvin, Phoebe and Joan Snyder Institute of Infection Immunity and Inflammation, University of Calgary, 1877 HSC, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, CanadaGastrointestinal Research Group, Department of Physiology and Pharmacology, The Calvin, Phoebe and Joan Snyder Institute of Infection Immunity and Inflammation, 1877 HSC University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, CanadaGastrointestinal Research Group, Department of Physiology and Pharmacology, The Calvin, Phoebe and Joan Snyder Institute of Infection Immunity and Inflammation, 1877 HSC University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, CanadaThere is an urgent need to develop better therapeutics for autoimmune and autoinflammatory diseases, of which musculoskeletal disorders such as rheumatoid arthritis are particularly prevalent and debilitating. Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. Substantial proof-of-principal data supporting the concept that infection with helminth parasites can reduce the severity of concomitant disease has been amassed from models of mucosal inflammation. Indeed, infection with helminth parasites has been tried as a therapy in inflammatory bowel disease, and there are case reports relating to other conditions (e.g., autism); however, the impact of infection with parasitic helminths on musculoskeletal diseases has not been extensively studied. Here, we present the view that such a strategy should be applied to the amelioration of joint inflammation and review the literature that supports this contention.http://dx.doi.org/10.1155/2011/942616 |
| spellingShingle | Chelsea E. Matisz Jason J. McDougall Keith A. Sharkey Derek M. McKay Helminth Parasites and the Modulation of Joint Inflammation Journal of Parasitology Research |
| title | Helminth Parasites and the Modulation of Joint Inflammation |
| title_full | Helminth Parasites and the Modulation of Joint Inflammation |
| title_fullStr | Helminth Parasites and the Modulation of Joint Inflammation |
| title_full_unstemmed | Helminth Parasites and the Modulation of Joint Inflammation |
| title_short | Helminth Parasites and the Modulation of Joint Inflammation |
| title_sort | helminth parasites and the modulation of joint inflammation |
| url | http://dx.doi.org/10.1155/2011/942616 |
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