The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery

The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery

Summary: Hairpin-forming CAG/CTG repeats pose significant challenges to DNA replication. In S. cerevisiae, long CAG/CTG repeat tracts reposition from the interior of the nucleus to the nuclear pore complex (NPC) to maintain their integrity. We show that relocation of a (CAG/CTG)130 tract to the NPC...

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Bibliographic Details
Main Authors: Tyler M. Maclay, Jenna M. Whalen, Matthew J. Johnson, Catherine H. Freudenreich
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500854X
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