Preclinical research models for endometrial cancer: development and selection of animal models
Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1512616/full |
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| author | Yang Xue Wei Shi Bing Lun Meilin Kan Mengling Jia Yuelin Wu Li Yang Li Yang |
| author_facet | Yang Xue Wei Shi Bing Lun Meilin Kan Mengling Jia Yuelin Wu Li Yang Li Yang |
| author_sort | Yang Xue |
| collection | DOAJ |
| description | Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models. The use of spontaneous and chemically-induced models has decreased, with transgenic mouse and xenograft models becoming the most widely used. These models better simulate tumor molecular mechanisms and treatments, with the organoid-based patient-derived xenograft model (O-PDX) showing great promise in drug screening and personalized therapy. The application of humanized models remains limited due to technical challenges and high costs. In this review, we highlight the strengths and limitations of each model to guide researchers in their selection. |
| format | Article |
| id | doaj-art-06bf5a8390554641a79532e2460a6df0 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-06bf5a8390554641a79532e2460a6df02025-02-05T05:17:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15126161512616Preclinical research models for endometrial cancer: development and selection of animal modelsYang Xue0Wei Shi1Bing Lun2Meilin Kan3Mengling Jia4Yuelin Wu5Li Yang6Li Yang7Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment, Zhengzhou, ChinaEndometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models. The use of spontaneous and chemically-induced models has decreased, with transgenic mouse and xenograft models becoming the most widely used. These models better simulate tumor molecular mechanisms and treatments, with the organoid-based patient-derived xenograft model (O-PDX) showing great promise in drug screening and personalized therapy. The application of humanized models remains limited due to technical challenges and high costs. In this review, we highlight the strengths and limitations of each model to guide researchers in their selection.https://www.frontiersin.org/articles/10.3389/fonc.2025.1512616/fullendometrial canceranimal modelpreclinical researchpatient-derived xenograft modelhumanized modelorganoid |
| spellingShingle | Yang Xue Wei Shi Bing Lun Meilin Kan Mengling Jia Yuelin Wu Li Yang Li Yang Preclinical research models for endometrial cancer: development and selection of animal models Frontiers in Oncology endometrial cancer animal model preclinical research patient-derived xenograft model humanized model organoid |
| title | Preclinical research models for endometrial cancer: development and selection of animal models |
| title_full | Preclinical research models for endometrial cancer: development and selection of animal models |
| title_fullStr | Preclinical research models for endometrial cancer: development and selection of animal models |
| title_full_unstemmed | Preclinical research models for endometrial cancer: development and selection of animal models |
| title_short | Preclinical research models for endometrial cancer: development and selection of animal models |
| title_sort | preclinical research models for endometrial cancer development and selection of animal models |
| topic | endometrial cancer animal model preclinical research patient-derived xenograft model humanized model organoid |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1512616/full |
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