Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature
Cryptococcus neoformans is an opportunistic yeast present in the environment. Practitioners are familiar with the presentation and management of the most common manifestation of cryptococcal infection, meningoencephalitis, in patients with AIDS or other conditions of immunocompromise. There is less...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/131356 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565004340035584 |
|---|---|
| author | Jennifer Wang Luther Bartelt Deborah Yu Anjali Joshi Bradley Weinbaum Tiffany Pierson Michael Patrizio Cirle A. Warren Molly A. Hughes Gerald Donowitz |
| author_facet | Jennifer Wang Luther Bartelt Deborah Yu Anjali Joshi Bradley Weinbaum Tiffany Pierson Michael Patrizio Cirle A. Warren Molly A. Hughes Gerald Donowitz |
| author_sort | Jennifer Wang |
| collection | DOAJ |
| description | Cryptococcus neoformans is an opportunistic yeast present in the environment. Practitioners are familiar with the presentation and management of the most common manifestation of cryptococcal infection, meningoencephalitis, in patients with AIDS or other conditions of immunocompromise. There is less awareness, however, of uncommon presentations where experience rather than evidence guides therapy. We report a case of primary cutaneous cryptococcosis (PCC) in a patient who had been immunosuppressed by chronic high-dose corticosteroid for the treatment of severe asthma. This case highlights the importance of early recognition of aggressive cellulitis that fails standard empiric antibiotic treatment in an immunocompromised patient. It also demonstrates successful treatment of PCC with a multispecialty approach including local debridement and fluconazole monotherapy. |
| format | Article |
| id | doaj-art-06ada05c37d948d691bfdd3354f4607a |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-06ada05c37d948d691bfdd3354f4607a2025-02-03T01:09:41ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/131356131356Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the LiteratureJennifer Wang0Luther Bartelt1Deborah Yu2Anjali Joshi3Bradley Weinbaum4Tiffany Pierson5Michael Patrizio6Cirle A. Warren7Molly A. Hughes8Gerald Donowitz9School of Medicine, University of Virginia, Charlottesville, VA 22903, USADivision of Infectious Diseases, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Plastic and Maxillofacial Surgery, University of Virginia, Charlottesville, VA 22903, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADivision of Infectious Diseases, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADivision of Infectious Diseases, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USADivision of Infectious Diseases, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USACryptococcus neoformans is an opportunistic yeast present in the environment. Practitioners are familiar with the presentation and management of the most common manifestation of cryptococcal infection, meningoencephalitis, in patients with AIDS or other conditions of immunocompromise. There is less awareness, however, of uncommon presentations where experience rather than evidence guides therapy. We report a case of primary cutaneous cryptococcosis (PCC) in a patient who had been immunosuppressed by chronic high-dose corticosteroid for the treatment of severe asthma. This case highlights the importance of early recognition of aggressive cellulitis that fails standard empiric antibiotic treatment in an immunocompromised patient. It also demonstrates successful treatment of PCC with a multispecialty approach including local debridement and fluconazole monotherapy.http://dx.doi.org/10.1155/2015/131356 |
| spellingShingle | Jennifer Wang Luther Bartelt Deborah Yu Anjali Joshi Bradley Weinbaum Tiffany Pierson Michael Patrizio Cirle A. Warren Molly A. Hughes Gerald Donowitz Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature Case Reports in Infectious Diseases |
| title | Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature |
| title_full | Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature |
| title_fullStr | Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature |
| title_full_unstemmed | Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature |
| title_short | Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature |
| title_sort | primary cutaneous cryptococcosis treated with debridement and fluconazole monotherapy in an immunosuppressed patient a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2015/131356 |
| work_keys_str_mv | AT jenniferwang primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT lutherbartelt primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT deborahyu primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT anjalijoshi primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT bradleyweinbaum primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT tiffanypierson primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT michaelpatrizio primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT cirleawarren primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT mollyahughes primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature AT geralddonowitz primarycutaneouscryptococcosistreatedwithdebridementandfluconazolemonotherapyinanimmunosuppressedpatientacasereportandreviewoftheliterature |