A Concise Review of Hepatitis C in Heart and Lung Transplantation
Hepatitis C (HCV) infection is prevalent in recipients of, and candidates for, solid organ transplants. The outcomes of HCV infection in cardiac and lung transplant recipients have yet to be clearly established, and future prospective studies are needed. In the absence of safe and effective antivira...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2011/947838 |
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| _version_ | 1849305630573068288 |
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| author | Edward Kim Hin Hin Ko Eric M Yoshida |
| author_facet | Edward Kim Hin Hin Ko Eric M Yoshida |
| author_sort | Edward Kim |
| collection | DOAJ |
| description | Hepatitis C (HCV) infection is prevalent in recipients of, and candidates for, solid organ transplants. The outcomes of HCV infection in cardiac and lung transplant recipients have yet to be clearly established, and future prospective studies are needed. In the absence of safe and effective antiviral treatment for HCV infection in heart and lung transplant recipients, the management of these patients remains a challenge and must be considered on an individual basis. Interferon therapy for HCV before transplantation appears to improve outcomes; however, post-transplant interferon therapy in the cardiac and pulmonary transplant setting may be associated with an increased risk of graft rejection. Given the paucity of information regarding HCV treatment in these transplant recipients, and with appropriate concerns that graft loss from rejection may not be amenable to a second transplant (given the scarcity of suitable cadaveric organs), multicentre, randomized controlled trials are needed to determine the optimal approach for treatment of HCV infection in this population. |
| format | Article |
| id | doaj-art-06a97d1967984b89b29d8a8d90a3feb2 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-06a97d1967984b89b29d8a8d90a3feb22025-08-20T03:55:23ZengWileyCanadian Journal of Gastroenterology0835-79002011-01-0125844544810.1155/2011/947838A Concise Review of Hepatitis C in Heart and Lung TransplantationEdward Kim0Hin Hin Ko1Eric M Yoshida2Gastroenterology Fellowship Program, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Gastroenterology, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Gastroenterology, University of British Columbia, Vancouver, British Columbia, CanadaHepatitis C (HCV) infection is prevalent in recipients of, and candidates for, solid organ transplants. The outcomes of HCV infection in cardiac and lung transplant recipients have yet to be clearly established, and future prospective studies are needed. In the absence of safe and effective antiviral treatment for HCV infection in heart and lung transplant recipients, the management of these patients remains a challenge and must be considered on an individual basis. Interferon therapy for HCV before transplantation appears to improve outcomes; however, post-transplant interferon therapy in the cardiac and pulmonary transplant setting may be associated with an increased risk of graft rejection. Given the paucity of information regarding HCV treatment in these transplant recipients, and with appropriate concerns that graft loss from rejection may not be amenable to a second transplant (given the scarcity of suitable cadaveric organs), multicentre, randomized controlled trials are needed to determine the optimal approach for treatment of HCV infection in this population.http://dx.doi.org/10.1155/2011/947838 |
| spellingShingle | Edward Kim Hin Hin Ko Eric M Yoshida A Concise Review of Hepatitis C in Heart and Lung Transplantation Canadian Journal of Gastroenterology |
| title | A Concise Review of Hepatitis C in Heart and Lung Transplantation |
| title_full | A Concise Review of Hepatitis C in Heart and Lung Transplantation |
| title_fullStr | A Concise Review of Hepatitis C in Heart and Lung Transplantation |
| title_full_unstemmed | A Concise Review of Hepatitis C in Heart and Lung Transplantation |
| title_short | A Concise Review of Hepatitis C in Heart and Lung Transplantation |
| title_sort | concise review of hepatitis c in heart and lung transplantation |
| url | http://dx.doi.org/10.1155/2011/947838 |
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