Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel
Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with div...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ticks and Tick-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1877959X24001249 |
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| author | Kate Halsby Gerhard Dobler Ava Easton Guntis Karelis Lenka Krbková Jan Kyncl Johann Sellner Franc Strle Malin Veje Joanna Zajkowska Dace Zavadska Frederick J. Angulo Andreas Pilz Wilhelm Erber Meghan Gabriel Jon Russo Mark Price Harish Madhava Uta Katharina Meyding-Lamadé |
| author_facet | Kate Halsby Gerhard Dobler Ava Easton Guntis Karelis Lenka Krbková Jan Kyncl Johann Sellner Franc Strle Malin Veje Joanna Zajkowska Dace Zavadska Frederick J. Angulo Andreas Pilz Wilhelm Erber Meghan Gabriel Jon Russo Mark Price Harish Madhava Uta Katharina Meyding-Lamadé |
| author_sort | Kate Halsby |
| collection | DOAJ |
| description | Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise. Ten panellists representing 8 European countries participated in the Delphi exercise, with specialities in neurology, infectious disease, paediatrics, immunology, virology, and epidemiology. Panellists reached unanimous consensus on the need for a standardised, international categorisation system to capture both clinical presentation and severity of TBEV infection. Ideally, such a system should be feasible for use at bedside, be clear and easy to understand, and capture both the acute and follow-up phases of TBEV infection. Areas requiring further discussion were (1) the timepoints at which assessments should be made and (2) whether there should be a separate system for children. This Delphi panel study found that a critical gap persists in the absence of a feasible and practical classification system for TBEV infection. Specifically, the findings of our Delphi exercise highlight the need for the development of a user-friendly classification system that captures the acute and follow-up (i.e., outcome) phases of TBEV infection and optimally reflects both clinical presentation and severity. Development of a clinical categorisation system will enhance patient care and foster comparability among studies, thereby supporting treatment development, refining vaccine strategies, and fortifying public health surveillance. |
| format | Article |
| id | doaj-art-069ef313c6ae4da2a5b07b934847e60d |
| institution | Kabale University |
| issn | 1877-9603 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ticks and Tick-Borne Diseases |
| spelling | doaj-art-069ef313c6ae4da2a5b07b934847e60d2025-02-05T04:31:31ZengElsevierTicks and Tick-Borne Diseases1877-96032025-01-01161102431Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panelKate Halsby0Gerhard Dobler1Ava Easton2Guntis Karelis3Lenka Krbková4Jan Kyncl5Johann Sellner6Franc Strle7Malin Veje8Joanna Zajkowska9Dace Zavadska10Frederick J. Angulo11Andreas Pilz12Wilhelm Erber13Meghan Gabriel14Jon Russo15Mark Price16Harish Madhava17Uta Katharina Meyding-Lamadé18Vaccines and Antivirals Medical Affairs, Pfizer Ltd, Surrey, United Kingdom; Corresponding author at: Pfizer Inc, Walton Oaks, Dorking Road, Tadworth, Surrey, KT20 7NS, United Kingdom.Bundeswehr Institute of Microbiology, Munich, Germany; Department of Infectious Diseases and Tropical Medicine, University Munich, GermanyEncephalitis International, North Yorkshire, United Kingdom; Institute of Infection, Veterinary and Ecological Science, University of Liverpool, NIHR HPRU for Emerging and Zoonotic Infection, Liverpool, United KingdomRīga Stradiņš University, Dzirciema St. 16, Rīga, LV-1007, Latvia; Rīga East University Hospital, Hipokrata St. 2, Rīga, LV-1079, LatviaDepartment of Pediatric Infectious Diseases, Faculty of Medicine, Masaryk University and Faculty Hospital, Brno, Czech RepublicDepartment of Infectious Diseases Epidemiology, National Institute of Public Health, Srobarova 49, Prague, Czech Republic; Department of Epidemiology and Biostatistics, Third Faculty of Medicine, Charles University, Ruska 87, Prague, Czech RepublicDepartment of Neurology, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Affiliated with Karl Landsteiner University of Health Sciences, Krems, AustriaDepartment of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, SloveniaDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at Gothenburg University, Guldhedsgatan 10, 41346, Gothenburg, SwedenDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Żurawia 14, Białystok 15-540, PolandRiga Stradins University, Department of Paediatrics, Children Clinical University Hospital, Riga, Vienibas gatve 45, Riga, LV1004, LatviaVaccines and Antivirals Medical Affairs, Pfizer Biopharma Group, 500 Arcola Rd, Collegeville, PA,19426, United StatesVaccines and Antivirals Medical Affairs, Pfizer Corporation Austria, Vienna, AustriaVaccines and Antivirals Medical Affairs, Pfizer Corporation Austria, Vienna, AustriaRTI Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, NC, United StatesRTI Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, NC, United StatesRTI Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, NC, United StatesVaccines and Antivirals Medical Affairs, Pfizer Ltd, Surrey, United KingdomKrankenhaus Nordwest, Frankfurt, GermanyCategorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise. Ten panellists representing 8 European countries participated in the Delphi exercise, with specialities in neurology, infectious disease, paediatrics, immunology, virology, and epidemiology. Panellists reached unanimous consensus on the need for a standardised, international categorisation system to capture both clinical presentation and severity of TBEV infection. Ideally, such a system should be feasible for use at bedside, be clear and easy to understand, and capture both the acute and follow-up phases of TBEV infection. Areas requiring further discussion were (1) the timepoints at which assessments should be made and (2) whether there should be a separate system for children. This Delphi panel study found that a critical gap persists in the absence of a feasible and practical classification system for TBEV infection. Specifically, the findings of our Delphi exercise highlight the need for the development of a user-friendly classification system that captures the acute and follow-up (i.e., outcome) phases of TBEV infection and optimally reflects both clinical presentation and severity. Development of a clinical categorisation system will enhance patient care and foster comparability among studies, thereby supporting treatment development, refining vaccine strategies, and fortifying public health surveillance.http://www.sciencedirect.com/science/article/pii/S1877959X24001249Delphi panelTick-borne encephalitisCategorisationDisease severity |
| spellingShingle | Kate Halsby Gerhard Dobler Ava Easton Guntis Karelis Lenka Krbková Jan Kyncl Johann Sellner Franc Strle Malin Veje Joanna Zajkowska Dace Zavadska Frederick J. Angulo Andreas Pilz Wilhelm Erber Meghan Gabriel Jon Russo Mark Price Harish Madhava Uta Katharina Meyding-Lamadé Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel Ticks and Tick-Borne Diseases Delphi panel Tick-borne encephalitis Categorisation Disease severity |
| title | Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel |
| title_full | Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel |
| title_fullStr | Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel |
| title_full_unstemmed | Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel |
| title_short | Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel |
| title_sort | evaluating the need for standardised disease manifestation categories in patients infected with the tick borne encephalitis virus a delphi panel |
| topic | Delphi panel Tick-borne encephalitis Categorisation Disease severity |
| url | http://www.sciencedirect.com/science/article/pii/S1877959X24001249 |
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