Objective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patient...
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Thieme Revinter Publicações
2013-03-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300137&lng=en&tlng=en |
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| author | Yára Dadalti Fragoso Soniza Vieira Alves-Leon Walter Oleschko Arruda Margarete de Jesus Carvalho Elizabeth Regina Comini-Frota Éber Castro Corrêa Maria Lucia Brito Ferreira Paulo Diniz da Gama Sidney Gomes Marcus Vinicius Magno Gonçalves Damacio Ramón Kaimen-Maciel Maria Fernanda Mendes Rogerio Rizo Morales Andre Muniz Pedro Rippel Salgado Heloisa Helena Ruocco Livia Brito Bezerra de Albuquerque Joseph Bruno Bidin Brooks Letícia Fêzer Sergio Georgetto Josiane Lopes Fabíola Rachid Malfetano Isabella D'Andrea Meira Celso Luis Silva Oliveira Francisco Tomaz Meneses de Oliveira Fabiana Safanelli Massaco Satomi |
| author_facet | Yára Dadalti Fragoso Soniza Vieira Alves-Leon Walter Oleschko Arruda Margarete de Jesus Carvalho Elizabeth Regina Comini-Frota Éber Castro Corrêa Maria Lucia Brito Ferreira Paulo Diniz da Gama Sidney Gomes Marcus Vinicius Magno Gonçalves Damacio Ramón Kaimen-Maciel Maria Fernanda Mendes Rogerio Rizo Morales Andre Muniz Pedro Rippel Salgado Heloisa Helena Ruocco Livia Brito Bezerra de Albuquerque Joseph Bruno Bidin Brooks Letícia Fêzer Sergio Georgetto Josiane Lopes Fabíola Rachid Malfetano Isabella D'Andrea Meira Celso Luis Silva Oliveira Francisco Tomaz Meneses de Oliveira Fabiana Safanelli Massaco Satomi |
| author_sort | Yára Dadalti Fragoso |
| collection | DOAJ |
| description | Objective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nine patients (76.7%) did not present any AE. Twenty-four patients (23.3%) presented only mild AE. There were three major AE, including two deaths. These three occurrences, although not necessarily being drug-related, must be taken into consideration. Conclusion The profile of AEs for natalizumab shows that 97% of patients have none or only mild AE. However, still due to safety worries, the use of this medication should be restricted to MS units under the care of specialized neurologists. |
| format | Article |
| id | doaj-art-066c2247473b4a5b8af6ac9f4fa33e26 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-066c2247473b4a5b8af6ac9f4fa33e262025-08-20T01:59:21ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272013-03-0171313714110.1590/S0004-282X2013000300002S0004-282X2013000300137Yára Dadalti FragosoSoniza Vieira Alves-LeonWalter Oleschko ArrudaMargarete de Jesus CarvalhoElizabeth Regina Comini-FrotaÉber Castro CorrêaMaria Lucia Brito FerreiraPaulo Diniz da GamaSidney GomesMarcus Vinicius Magno GonçalvesDamacio Ramón Kaimen-MacielMaria Fernanda MendesRogerio Rizo MoralesAndre MunizPedro Rippel SalgadoHeloisa Helena RuoccoLivia Brito Bezerra de AlbuquerqueJoseph Bruno Bidin BrooksLetícia FêzerSergio GeorgettoJosiane LopesFabíola Rachid MalfetanoIsabella D'Andrea MeiraCelso Luis Silva OliveiraFrancisco Tomaz Meneses de OliveiraFabiana SafanelliMassaco SatomiObjective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nine patients (76.7%) did not present any AE. Twenty-four patients (23.3%) presented only mild AE. There were three major AE, including two deaths. These three occurrences, although not necessarily being drug-related, must be taken into consideration. Conclusion The profile of AEs for natalizumab shows that 97% of patients have none or only mild AE. However, still due to safety worries, the use of this medication should be restricted to MS units under the care of specialized neurologists.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300137&lng=en&tlng=enesclerose múltiplanatalizumabeeventos adversosanticorpos monoclonais |
| spellingShingle | Yára Dadalti Fragoso Soniza Vieira Alves-Leon Walter Oleschko Arruda Margarete de Jesus Carvalho Elizabeth Regina Comini-Frota Éber Castro Corrêa Maria Lucia Brito Ferreira Paulo Diniz da Gama Sidney Gomes Marcus Vinicius Magno Gonçalves Damacio Ramón Kaimen-Maciel Maria Fernanda Mendes Rogerio Rizo Morales Andre Muniz Pedro Rippel Salgado Heloisa Helena Ruocco Livia Brito Bezerra de Albuquerque Joseph Bruno Bidin Brooks Letícia Fêzer Sergio Georgetto Josiane Lopes Fabíola Rachid Malfetano Isabella D'Andrea Meira Celso Luis Silva Oliveira Francisco Tomaz Meneses de Oliveira Fabiana Safanelli Massaco Satomi Arquivos de Neuro-Psiquiatria esclerose múltipla natalizumabe eventos adversos anticorpos monoclonais |
| topic | esclerose múltipla natalizumabe eventos adversos anticorpos monoclonais |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300137&lng=en&tlng=en |