Association between diabetes mellitus and tinnitus: A meta-analysis
Diabetes mellitus (DM) has been suggested as a potential risk factor for tinnitus, but evidence remains inconclusive. This meta-analysis aimed to evaluate the association between DM and tinnitus by systematically reviewing and synthesizing data from observational studies. A comprehensive literature...
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| Format: | Article |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-01-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://bjbms.org/ojs/index.php/bjbms/article/view/11634 |
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| author | Shi Luo Jianxue Wen Qilong Bao Haibo Ou Shuting Yi Peng Peng |
| author_facet | Shi Luo Jianxue Wen Qilong Bao Haibo Ou Shuting Yi Peng Peng |
| author_sort | Shi Luo |
| collection | DOAJ |
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Diabetes mellitus (DM) has been suggested as a potential risk factor for tinnitus, but evidence remains inconclusive. This meta-analysis aimed to evaluate the association between DM and tinnitus by systematically reviewing and synthesizing data from observational studies. A comprehensive literature search was conducted in PubMed, Embase, and Web of Science up to August 16, 2024. Observational studies with a sample size of at least 100 participants that assessed the relationship between DM and tinnitus were included. Studies involving populations with specific diseases were excluded. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and sensitivity and subgroup analyses were performed. Publication bias was evaluated using funnel plots and Egger’s regression test. Twelve studies comprising 2,277,719 participants were included. The pooled analysis revealed a significant association between DM and tinnitus (OR: 1.18, 95% CI: 1.06–1.31, P = 0.002), with moderate heterogeneity (I² = 51%). Sensitivity analyses confirmed the robustness of these findings. Subgroup analyses showed no significant differences by geographical region, mean age, sex distribution, tinnitus diagnosis method, or model used for association estimation. Publication bias was not detected (Egger’s test P = 0.29). These findings suggest that DM is significantly associated with an increased risk of tinnitus. Further research is warranted to explore underlying mechanisms and causal relationships. Nonetheless, the results underscore the importance of monitoring tinnitus in patients with diabetes.
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| format | Article |
| id | doaj-art-0662bcdef3a0491ab88e8178fb01460e |
| institution | Kabale University |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-0662bcdef3a0491ab88e8178fb01460e2025-02-03T16:42:10ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-01-0110.17305/bb.2024.11634Association between diabetes mellitus and tinnitus: A meta-analysisShi Luo0Jianxue Wen1Qilong Bao2Haibo Ou3Shuting Yi4Peng Peng5Department of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, Xiangya Second Hospital of Central South University, Changsha, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, China Diabetes mellitus (DM) has been suggested as a potential risk factor for tinnitus, but evidence remains inconclusive. This meta-analysis aimed to evaluate the association between DM and tinnitus by systematically reviewing and synthesizing data from observational studies. A comprehensive literature search was conducted in PubMed, Embase, and Web of Science up to August 16, 2024. Observational studies with a sample size of at least 100 participants that assessed the relationship between DM and tinnitus were included. Studies involving populations with specific diseases were excluded. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and sensitivity and subgroup analyses were performed. Publication bias was evaluated using funnel plots and Egger’s regression test. Twelve studies comprising 2,277,719 participants were included. The pooled analysis revealed a significant association between DM and tinnitus (OR: 1.18, 95% CI: 1.06–1.31, P = 0.002), with moderate heterogeneity (I² = 51%). Sensitivity analyses confirmed the robustness of these findings. Subgroup analyses showed no significant differences by geographical region, mean age, sex distribution, tinnitus diagnosis method, or model used for association estimation. Publication bias was not detected (Egger’s test P = 0.29). These findings suggest that DM is significantly associated with an increased risk of tinnitus. Further research is warranted to explore underlying mechanisms and causal relationships. Nonetheless, the results underscore the importance of monitoring tinnitus in patients with diabetes. https://bjbms.org/ojs/index.php/bjbms/article/view/11634Tinnitusdiabetes mellitusDMprevalencerisk factor meta-analysis |
| spellingShingle | Shi Luo Jianxue Wen Qilong Bao Haibo Ou Shuting Yi Peng Peng Association between diabetes mellitus and tinnitus: A meta-analysis Biomolecules & Biomedicine Tinnitus diabetes mellitus DM prevalence risk factor meta-analysis |
| title | Association between diabetes mellitus and tinnitus: A meta-analysis |
| title_full | Association between diabetes mellitus and tinnitus: A meta-analysis |
| title_fullStr | Association between diabetes mellitus and tinnitus: A meta-analysis |
| title_full_unstemmed | Association between diabetes mellitus and tinnitus: A meta-analysis |
| title_short | Association between diabetes mellitus and tinnitus: A meta-analysis |
| title_sort | association between diabetes mellitus and tinnitus a meta analysis |
| topic | Tinnitus diabetes mellitus DM prevalence risk factor meta-analysis |
| url | https://bjbms.org/ojs/index.php/bjbms/article/view/11634 |
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