Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm
In this work, a new solution has been found for selecting the approximate initial value of concentration (by means of the classical least squares) and variance (calculated by the Horwitz equation) for the Kalman filter algorithm. With this solution, the Kalman method is less error-prone and has a be...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2019/5719651 |
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| author | Nguyen Thi Quynh Trang Nguyen Van Hop Nguyen Dang Giang Chau Thuc Binh Tran |
| author_facet | Nguyen Thi Quynh Trang Nguyen Van Hop Nguyen Dang Giang Chau Thuc Binh Tran |
| author_sort | Nguyen Thi Quynh Trang |
| collection | DOAJ |
| description | In this work, a new solution has been found for selecting the approximate initial value of concentration (by means of the classical least squares) and variance (calculated by the Horwitz equation) for the Kalman filter algorithm. With this solution, the Kalman method is less error-prone and has a better repeatability than the least squares method when using the full spectrum. A protocol for simultaneous determination of amlodipine (AML), hydrochlorothiazide (HYD), and valsartan (VAL) in pharmaceutical products was developed based on the spectrophotometry-chemometric method using full spectrum measurement in combination with the Kalman filter algorithm written in Microsoft Excel 2016 and Visual Basic for Applications (VBA). The method was validated on the Exforge HCT tablets with good repeatability (RSD) (varied from 2.2% to 2.3% (n = 3) for all the three studied compounds) and good recovery (90.0%–94.0% for AML, 90.3%–94.5% for HYD, and 98.5%–103.1% for VAL (n = 3)). The results were in good agreement with the measurements achieved from the high-performance liquid chromatography (HPLC) method. |
| format | Article |
| id | doaj-art-065884019d67495e942351cc0d17cdfe |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-065884019d67495e942351cc0d17cdfe2025-02-03T06:14:12ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422019-01-01201910.1155/2019/57196515719651Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter AlgorithmNguyen Thi Quynh Trang0Nguyen Van Hop1Nguyen Dang Giang Chau2Thuc Binh Tran3University of Sciences, Hue University, Hue 530000, VietnamUniversity of Sciences, Hue University, Hue 530000, VietnamUniversity of Sciences, Hue University, Hue 530000, VietnamUniversity of Sciences, Hue University, Hue 530000, VietnamIn this work, a new solution has been found for selecting the approximate initial value of concentration (by means of the classical least squares) and variance (calculated by the Horwitz equation) for the Kalman filter algorithm. With this solution, the Kalman method is less error-prone and has a better repeatability than the least squares method when using the full spectrum. A protocol for simultaneous determination of amlodipine (AML), hydrochlorothiazide (HYD), and valsartan (VAL) in pharmaceutical products was developed based on the spectrophotometry-chemometric method using full spectrum measurement in combination with the Kalman filter algorithm written in Microsoft Excel 2016 and Visual Basic for Applications (VBA). The method was validated on the Exforge HCT tablets with good repeatability (RSD) (varied from 2.2% to 2.3% (n = 3) for all the three studied compounds) and good recovery (90.0%–94.0% for AML, 90.3%–94.5% for HYD, and 98.5%–103.1% for VAL (n = 3)). The results were in good agreement with the measurements achieved from the high-performance liquid chromatography (HPLC) method.http://dx.doi.org/10.1155/2019/5719651 |
| spellingShingle | Nguyen Thi Quynh Trang Nguyen Van Hop Nguyen Dang Giang Chau Thuc Binh Tran Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm Advances in Materials Science and Engineering |
| title | Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm |
| title_full | Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm |
| title_fullStr | Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm |
| title_full_unstemmed | Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm |
| title_short | Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm |
| title_sort | simultaneous determination of amlodipine hydrochlorothiazide and valsartan in pharmaceutical products by a combination of full spectrum measurement and kalman filter algorithm |
| url | http://dx.doi.org/10.1155/2019/5719651 |
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