Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants
Ruellia tuberosa L. leaf and root extracts have been investigated for their biological activity and potential health advantages, including their antidiabetic, antioxidant, and antidiuretic qualities. This research evaluates the freeze-drying microencapsulation of R. tuberosa L. extracts using gum Ar...
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Department of Chemistry, Universitas Gadjah Mada
2025-01-01
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| Series: | Indonesian Journal of Chemistry |
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| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/95246 |
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| author | Firza Rajasa Gunawan Siti Mariyah Ulfa Anna Safitri |
| author_facet | Firza Rajasa Gunawan Siti Mariyah Ulfa Anna Safitri |
| author_sort | Firza Rajasa Gunawan |
| collection | DOAJ |
| description | Ruellia tuberosa L. leaf and root extracts have been investigated for their biological activity and potential health advantages, including their antidiabetic, antioxidant, and antidiuretic qualities. This research evaluates the freeze-drying microencapsulation of R. tuberosa L. extracts using gum Arabic, maltodextrin, and their combination as coating materials. The resulting microcapsules were tested for encapsulation efficiency, biological activity, and controlled release. Characterization techniques included scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and particle size analysis (PSA). The choice of encapsulant significantly influenced encapsulation efficiency, morphology, and biological activity. Microcapsules using a combination of gum Arabic and maltodextrin exhibited more spherical shapes and smaller particle sizes than those using either material alone. Alpha-amylase inhibition tests showed that microcapsules effectively inhibit the enzyme, with the coating combination performing best, followed by gum Arabic and then maltodextrin. All microcapsules exhibit moderate antioxidant activity, again in the same order. The active compound release was greater at pH 7.4 compared to pH 2.2 from 0 to 120 min. Therefore, freeze-drying microencapsulation with biodegradable polymers is a viable method for delivering the health benefits of R. tuberosa L. extracts, yielding a convenient powder form suitable for drug delivery systems. |
| format | Article |
| id | doaj-art-0653e84d1b3b4cc08ad93535c19afe1e |
| institution | Kabale University |
| issn | 1411-9420 2460-1578 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj-art-0653e84d1b3b4cc08ad93535c19afe1e2025-02-03T04:32:43ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782025-01-01251374910.22146/ijc.9524636648Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as EncapsulantsFirza Rajasa Gunawan0Siti Mariyah Ulfa1Anna Safitri2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, Indonesia; Research Center of SMONAGENES (Smart Molecules of Natural Genetic Resources), Brawijaya University, Jl. Veteran, Malang 65145, IndonesiaRuellia tuberosa L. leaf and root extracts have been investigated for their biological activity and potential health advantages, including their antidiabetic, antioxidant, and antidiuretic qualities. This research evaluates the freeze-drying microencapsulation of R. tuberosa L. extracts using gum Arabic, maltodextrin, and their combination as coating materials. The resulting microcapsules were tested for encapsulation efficiency, biological activity, and controlled release. Characterization techniques included scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and particle size analysis (PSA). The choice of encapsulant significantly influenced encapsulation efficiency, morphology, and biological activity. Microcapsules using a combination of gum Arabic and maltodextrin exhibited more spherical shapes and smaller particle sizes than those using either material alone. Alpha-amylase inhibition tests showed that microcapsules effectively inhibit the enzyme, with the coating combination performing best, followed by gum Arabic and then maltodextrin. All microcapsules exhibit moderate antioxidant activity, again in the same order. The active compound release was greater at pH 7.4 compared to pH 2.2 from 0 to 120 min. Therefore, freeze-drying microencapsulation with biodegradable polymers is a viable method for delivering the health benefits of R. tuberosa L. extracts, yielding a convenient powder form suitable for drug delivery systems.https://jurnal.ugm.ac.id/ijc/article/view/95246gum arabicfreeze-dryingmaltodextrinmicroencapsulationr. tuberosa l. |
| spellingShingle | Firza Rajasa Gunawan Siti Mariyah Ulfa Anna Safitri Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants Indonesian Journal of Chemistry gum arabic freeze-drying maltodextrin microencapsulation r. tuberosa l. |
| title | Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants |
| title_full | Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants |
| title_fullStr | Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants |
| title_full_unstemmed | Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants |
| title_short | Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants |
| title_sort | freeze drying microencapsulation of i ruellia tuberosa i l extracts a comparative study using different polymers as encapsulants |
| topic | gum arabic freeze-drying maltodextrin microencapsulation r. tuberosa l. |
| url | https://jurnal.ugm.ac.id/ijc/article/view/95246 |
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