Development and Validation of an LC–MS/MS Method for Quantifying Gabapentin in Plasma: Application to a Pharmacokinetic Study in Cats

Development and Validation of an LC–MS/MS Method for Quantifying Gabapentin in Plasma: Application to a Pharmacokinetic Study in Cats

Gabapentin (GBP), a γ-aminobutyric acid analogue used for neuropathic pain and epilepsy, can reduce cat stress and improve veterinary exam compliance. A sensitive LC-MS/MS assay was established and rigorously validated for quantifying GBP in feline plasma. The method employed acetonitrile-mediated p...

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Bibliographic Details
Main Authors: Feifei Zhao, Changcheng Lin, Yunying Wu, Xinyue Luo, Ning Han, Wenguang Xiong, Zhenling Zeng
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Animals
Subjects:
gabapentin
LC-MS/MS
cat plasma
pharmacokinetics
Online Access:https://www.mdpi.com/2076-2615/15/7/950
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