P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury

P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury

The aim of this study was to investigate the effect of the P2Y2 receptor (P2Y2R) signaling pathway on neuronal regeneration and angiogenesis during spinal cord injury (SCI). The rats were randomly divided into 3 groups, including the sham+dimethyl sulfoxide (DMSO), SCI+DMSO, and SCI+P2Y2R groups. Th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ruidong Cheng, Genying Zhu, Chengtao Ni, Rui Wang, Peng Sun, Liang Tian, Li Zhang, Jie Zhang, Xiangming Ye, Benyan Luo
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Neural Plasticity
Online Access:	http://dx.doi.org/10.1155/2022/2191011
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination
by: Xinyu Fang, et al.
Published: (2019-01-01)

A Review on Locomotor Training after Spinal Cord Injury: Reorganization of Spinal Neuronal Circuits and Recovery of Motor Function
by: Andrew C. Smith, et al.
Published: (2016-01-01)

Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury
by: Baoguo Liu, et al.
Published: (2023-01-01)

Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo
by: Ellen D. Stück, et al.
Published: (2012-01-01)

GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus
by: Kei Hori, et al.
Published: (2012-01-01)

Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling
by: Kunlin Guo, et al.
Published: (2025-06-01)

Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration
by: Zhaoyang Gong, et al.
Published: (2025-01-01)

Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors
by: Yifan Yang, et al.
Published: (2022-01-01)

Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury
by: Xin Li, et al.
Published: (2023-01-01)

Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats
by: Tongxia Zhang, et al.
Published: (2025-01-01)

Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
by: Ping Li, et al.
Published: (2016-01-01)

Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury
by: Christian J. Entenmann, et al.
Published: (2025-01-01)

Neuroprotective and Neurorestorative Processes after Spinal Cord Injury: The Case of the Bulbospinal Respiratory Neurons
by: Anne Kastner, et al.
Published: (2016-01-01)

Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice
by: Elle EM Scheijen, et al.
Published: (2025-01-01)

Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice
by: Daoyong Li, et al.
Published: (2025-01-01)

Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury
by: Mary J. Eaton, et al.
Published: (2011-01-01)

The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury
by: Shmma Quraishe, et al.
Published: (2018-01-01)

The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
by: Callan L. Attwell, et al.
Published: (2025-02-01)

High-Dose Neural Stem/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Injury
by: Taoyang Yuan, et al.
Published: (2019-01-01)

AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury
by: Wen-Yuan Li, et al.
Published: (2017-01-01)

Physiopathological effects of entrance versus distal spread-out Bragg peak on mouse spinal cord neurons
by: Filippo Torrisi, et al.
Published: (2025-01-01)

The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity
by: Kathryn M. Madalena, et al.
Published: (2017-01-01)

Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery
by: Zacnicte May, et al.
Published: (2017-01-01)

EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury
by: Shuangfei Ni, et al.
Published: (2021-01-01)

Roles of Mesenchymal Stem Cells in Spinal Cord Injury
by: Jing Qu, et al.
Published: (2017-01-01)

IL-18 Blockage Reduces Neuroinflammation and Promotes Functional Recovery in a Mouse Model of Spinal Cord Injury
by: Easmin Begum, et al.
Published: (2024-12-01)

Can the Spinal Cord Learn and Remember?
by: Pierre A. Guertin
Published: (2008-01-01)

Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration
by: Xuan Li, et al.
Published: (2025-02-01)

Cannabinoid receptor 2 facilitates the Schwann cells‐dependent peripheral nerve regeneration
by: Heng Xu, et al.
Published: (2025-01-01)

Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network
by: Haiyang Yu, et al.
Published: (2025-01-01)

Activity-Dependent Plasticity of Spinal Circuits in the Developing and Mature Spinal Cord
by: Behdad Tahayori, et al.
Published: (2012-01-01)

Xenopus laevis neural stem progenitor cells exhibit a transient metabolic shift toward glycolysis during spinal cord regeneration
by: Paula G. Slater, et al.
Published: (2025-01-01)

Human Umbilical Cord Mesenchymal Stem Cells Encapsulated with Pluronic F-127 Enhance the Regeneration and Angiogenesis of Thin Endometrium in Rat via Local IL-1β Stimulation
by: Shuling Zhou, et al.
Published: (2022-01-01)

Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord injury: a double-blind randomized controlled clinical trial
by: Natalia Comino-Suárez, et al.
Published: (2025-01-01)

Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons
by: Jie Fu, et al.
Published: (2021-01-01)

Research Progress on Biomaterials for Spinal Cord Repair
by: Liao Z, et al.
Published: (2025-02-01)

Three-dimensional reconstruction of the spinal cord of thoroughbred
by: Durmuş Bolat

Spinal Cord Lesion: Effects of and Perspectives for Treatment
by: V. Dietz
Published: (2001-01-01)

The Potential of Curcumin in Treatment of Spinal Cord Injury
by: Raghavendra Sanivarapu, et al.
Published: (2016-01-01)

Spinal Cord Stroke: Acute Imaging and Intervention
by: Karen Lynch, et al.
Published: (2012-01-01)