Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy
The aims of your case report is to show the predictivity of Tc99m-sestamibi (MIBI) scintigraphy and doppler ultrasound imaging on secondary hyperparathyroidism (SHPT) in a patient responsive to calcimimetic treatment. Moreover, it has been reported that calcimimetic has great potential in reducing t...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/206801 |
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| author | Piergiorgio Bolasco Alessandra Serra Maurizio Loi Andrea Galfré Mario Piga |
| author_facet | Piergiorgio Bolasco Alessandra Serra Maurizio Loi Andrea Galfré Mario Piga |
| author_sort | Piergiorgio Bolasco |
| collection | DOAJ |
| description | The aims of your case report is to show the predictivity of Tc99m-sestamibi (MIBI) scintigraphy and doppler ultrasound imaging on secondary hyperparathyroidism (SHPT) in a patient responsive to calcimimetic treatment. Moreover, it has been reported that calcimimetic has great potential in reducing the volume of the parathyroid gland. On the other hand, the MIBI scintigraphy is considered a crucial diagnostic procedure to monitor the response to therapy in terms of turnover and cellular metabolism; whereas, ultrasound to monitor the volume variation in response to treatment. It is described the case of a 73-year-old man on hemodialysis from 1995 for ESRD. Within 2 years the patient gradually developed SHPT with progressively increased iPTH up to 1,000 ρg/ml. The ultrasound, highlighted the presence of two parathyroid hyperplasia, confirmed by scintigraphy, showing focal increase uptake of sestamibi in the same anatomical areas. As a result of the patient's refusal to perform a parathyroidectomy, cinacalcet, was administered (65 mg overage daily dose). After a year of treatment, there was a striking decrease of iPTH (from 1300 to 57 ρg/ml, −95%); but, on the contrary to expectations, this positive metabolic outcome, was not followed by parathyroid changes in ultrasound and scintigraphic findings. |
| format | Article |
| id | doaj-art-06304a73c84e4370adddb808e4ee68ca |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-06304a73c84e4370adddb808e4ee68ca2025-02-03T01:31:48ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/206801206801Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet TherapyPiergiorgio Bolasco0Alessandra Serra1Maurizio Loi2Andrea Galfré3Mario Piga4Territorial Nephrology and Dialysis Department, ASL, 8 Cagliari, via Turati 4/C-Quartu Sant'Elena, Cagliari, Sardinia, ItalyNuclear Medicine Department, Azienda Ospedaliero-Universitaria di Cagliari, 09124 Cagliari, ItalyRadiology Department, Azienda Ospedaliero-Universitaria di Cagliari, 09124 Cagliari, ItalyTerritorial Nephrology and Dialysis Department, ASL, 8 Cagliari, via Turati 4/C-Quartu Sant'Elena, Cagliari, Sardinia, ItalyNuclear Medicine Department, Azienda Ospedaliero-Universitaria di Cagliari, 09124 Cagliari, ItalyThe aims of your case report is to show the predictivity of Tc99m-sestamibi (MIBI) scintigraphy and doppler ultrasound imaging on secondary hyperparathyroidism (SHPT) in a patient responsive to calcimimetic treatment. Moreover, it has been reported that calcimimetic has great potential in reducing the volume of the parathyroid gland. On the other hand, the MIBI scintigraphy is considered a crucial diagnostic procedure to monitor the response to therapy in terms of turnover and cellular metabolism; whereas, ultrasound to monitor the volume variation in response to treatment. It is described the case of a 73-year-old man on hemodialysis from 1995 for ESRD. Within 2 years the patient gradually developed SHPT with progressively increased iPTH up to 1,000 ρg/ml. The ultrasound, highlighted the presence of two parathyroid hyperplasia, confirmed by scintigraphy, showing focal increase uptake of sestamibi in the same anatomical areas. As a result of the patient's refusal to perform a parathyroidectomy, cinacalcet, was administered (65 mg overage daily dose). After a year of treatment, there was a striking decrease of iPTH (from 1300 to 57 ρg/ml, −95%); but, on the contrary to expectations, this positive metabolic outcome, was not followed by parathyroid changes in ultrasound and scintigraphic findings.http://dx.doi.org/10.1155/2010/206801 |
| spellingShingle | Piergiorgio Bolasco Alessandra Serra Maurizio Loi Andrea Galfré Mario Piga Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy International Journal of Endocrinology |
| title | Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy |
| title_full | Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy |
| title_fullStr | Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy |
| title_full_unstemmed | Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy |
| title_short | Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy |
| title_sort | failed switching off in the mibi parathyroid scintigraphy in a dialyzed patient with secondary hyperparathyroidism responsive to cinacalcet therapy |
| url | http://dx.doi.org/10.1155/2010/206801 |
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