Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake
Fatty acid analyses of sperm and erythrocyte cell membrane phospholipids in idiopathic infertile patients evidenced that erythrocyte contents of EPA, DHA, omega-6–omega-3 ratio and arachidonic acid provide a mathematical correspondence for the prediction of EPA level in sperm cells. The erythrocyte...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2015/670526 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556447782666240 |
|---|---|
| author | Gabriela Ruth Mendeluk Mariano Isaac Cohen Carla Ferreri Chryssostomos Chatgilialoglu |
| author_facet | Gabriela Ruth Mendeluk Mariano Isaac Cohen Carla Ferreri Chryssostomos Chatgilialoglu |
| author_sort | Gabriela Ruth Mendeluk |
| collection | DOAJ |
| description | Fatty acid analyses of sperm and erythrocyte cell membrane phospholipids in idiopathic infertile patients evidenced that erythrocyte contents of EPA, DHA, omega-6–omega-3 ratio and arachidonic acid provide a mathematical correspondence for the prediction of EPA level in sperm cells. The erythrocyte lipidomic profile of patients was significantly altered, with signatures of typical Western pattern dietary habits and no fish intake. A supplementation with nutritional levels of EPA and DHA and antioxidants was then performed for 3 months, with the follow-up of both erythrocyte and sperm cell membranes composition as well as conventional sperm parameters. Some significant changes were found in the lipidomic membrane profile of erythrocyte but not in sperm cells, which correspondently did not show significant parameter ameliorations. This is the first report indicating that membrane lipids of different tissues do not equally metabolize the fatty acid elements upon supplementation. Molecular diagnostic tools are necessary to understand the cell metabolic turnover and monitor the success of nutraceuticals for personalized treatments. |
| format | Article |
| id | doaj-art-062956d1f4a442c982f1891f79adf331 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-062956d1f4a442c982f1891f79adf3312025-02-03T05:45:24ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322015-01-01201510.1155/2015/670526670526Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 IntakeGabriela Ruth Mendeluk0Mariano Isaac Cohen1Carla Ferreri2Chryssostomos Chatgilialoglu3Laboratory of Male Fertility, Hospital de Clínicas “José de San Martín”, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, 5950-800 Buenos Aires, ArgentinaUrology Division, Hospital de Clínicas “José de San Martín”, University of Buenos Aires, 5950-800 Buenos Aires, ArgentinaConsiglio Nazionale delle Ricerche (CNR), Istituto per la Sintesi Organica e la Fotoreattività (ISOF), 40129 Bologna, ItalyInstitute of Nanoscience and Nanotechnology, National Center of Scientific Research “Demokritos”, Agia Paraskevi, 15310 Athens, GreeceFatty acid analyses of sperm and erythrocyte cell membrane phospholipids in idiopathic infertile patients evidenced that erythrocyte contents of EPA, DHA, omega-6–omega-3 ratio and arachidonic acid provide a mathematical correspondence for the prediction of EPA level in sperm cells. The erythrocyte lipidomic profile of patients was significantly altered, with signatures of typical Western pattern dietary habits and no fish intake. A supplementation with nutritional levels of EPA and DHA and antioxidants was then performed for 3 months, with the follow-up of both erythrocyte and sperm cell membranes composition as well as conventional sperm parameters. Some significant changes were found in the lipidomic membrane profile of erythrocyte but not in sperm cells, which correspondently did not show significant parameter ameliorations. This is the first report indicating that membrane lipids of different tissues do not equally metabolize the fatty acid elements upon supplementation. Molecular diagnostic tools are necessary to understand the cell metabolic turnover and monitor the success of nutraceuticals for personalized treatments.http://dx.doi.org/10.1155/2015/670526 |
| spellingShingle | Gabriela Ruth Mendeluk Mariano Isaac Cohen Carla Ferreri Chryssostomos Chatgilialoglu Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake Journal of Nutrition and Metabolism |
| title | Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake |
| title_full | Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake |
| title_fullStr | Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake |
| title_full_unstemmed | Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake |
| title_short | Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and ω-3 Intake |
| title_sort | nutrition and reproductive health sperm versus erythrocyte lipidomic profile and ω 3 intake |
| url | http://dx.doi.org/10.1155/2015/670526 |
| work_keys_str_mv | AT gabrielaruthmendeluk nutritionandreproductivehealthspermversuserythrocytelipidomicprofileandō3intake AT marianoisaaccohen nutritionandreproductivehealthspermversuserythrocytelipidomicprofileandō3intake AT carlaferreri nutritionandreproductivehealthspermversuserythrocytelipidomicprofileandō3intake AT chryssostomoschatgilialoglu nutritionandreproductivehealthspermversuserythrocytelipidomicprofileandō3intake |