Rhabdomyolysis in Children: A State-of-the-Art Review
Rhabdomyolysis in pediatric patients is a rare but potentially life-threatening condition characterized by the breakdown of skeletal muscle fibers, leading to the release of intracellular components such as myoglobin, potassium, and creatine kinase into the bloodstream. This process can result in se...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/4/492 |
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| author | Manson Chon In Kuok Winnie Kwai Yu Chan |
| author_facet | Manson Chon In Kuok Winnie Kwai Yu Chan |
| author_sort | Manson Chon In Kuok |
| collection | DOAJ |
| description | Rhabdomyolysis in pediatric patients is a rare but potentially life-threatening condition characterized by the breakdown of skeletal muscle fibers, leading to the release of intracellular components such as myoglobin, potassium, and creatine kinase into the bloodstream. This process can result in severe electrolyte imbalances and acute kidney injury (AKI), sometimes necessitating kidney replacement therapy. While rhabdomyolysis is well studied in adults, pediatric cases present unique diagnostic and therapeutic challenges due to distinct etiologies and clinical manifestations. This review explores the pathophysiology, etiologies, complications, treatment, and outcomes of rhabdomyolysis, with a particular focus on the pediatric population. Emerging evidence regarding the role of hemoadsorption in myoglobin removal is discussed and summarized. Additionally, we propose a systematic framework for the management and monitoring of these patients. |
| format | Article |
| id | doaj-art-061f3b3d920d49c69e6745ab1914916f |
| institution | OA Journals |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-061f3b3d920d49c69e6745ab1914916f2025-08-20T02:28:27ZengMDPI AGChildren2227-90672025-04-0112449210.3390/children12040492Rhabdomyolysis in Children: A State-of-the-Art ReviewManson Chon In Kuok0Winnie Kwai Yu Chan1Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong, ChinaDepartment of Paediatrics, Queen Elizabeth Hospital, Hong Kong, ChinaRhabdomyolysis in pediatric patients is a rare but potentially life-threatening condition characterized by the breakdown of skeletal muscle fibers, leading to the release of intracellular components such as myoglobin, potassium, and creatine kinase into the bloodstream. This process can result in severe electrolyte imbalances and acute kidney injury (AKI), sometimes necessitating kidney replacement therapy. While rhabdomyolysis is well studied in adults, pediatric cases present unique diagnostic and therapeutic challenges due to distinct etiologies and clinical manifestations. This review explores the pathophysiology, etiologies, complications, treatment, and outcomes of rhabdomyolysis, with a particular focus on the pediatric population. Emerging evidence regarding the role of hemoadsorption in myoglobin removal is discussed and summarized. Additionally, we propose a systematic framework for the management and monitoring of these patients.https://www.mdpi.com/2227-9067/12/4/492rhabdomyolysismyositiscreatine kinaseacute kidney injury |
| spellingShingle | Manson Chon In Kuok Winnie Kwai Yu Chan Rhabdomyolysis in Children: A State-of-the-Art Review Children rhabdomyolysis myositis creatine kinase acute kidney injury |
| title | Rhabdomyolysis in Children: A State-of-the-Art Review |
| title_full | Rhabdomyolysis in Children: A State-of-the-Art Review |
| title_fullStr | Rhabdomyolysis in Children: A State-of-the-Art Review |
| title_full_unstemmed | Rhabdomyolysis in Children: A State-of-the-Art Review |
| title_short | Rhabdomyolysis in Children: A State-of-the-Art Review |
| title_sort | rhabdomyolysis in children a state of the art review |
| topic | rhabdomyolysis myositis creatine kinase acute kidney injury |
| url | https://www.mdpi.com/2227-9067/12/4/492 |
| work_keys_str_mv | AT mansonchoninkuok rhabdomyolysisinchildrenastateoftheartreview AT winniekwaiyuchan rhabdomyolysisinchildrenastateoftheartreview |