The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint

The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint

Summary: The methyl donor S-adenosylmethionine (SAM) regulates many cellular processes. The N6-methyladenosine (m6A) methyltransferase METTL16 regulates the expression of the SAM synthetase MAT2A, but the consequences of this regulation are not well documented. Here, we used a degron and complementa...

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Bibliographic Details
Main Authors: Juliana N. Flaherty, Enakshi Sivasudhan, Matthew Tegowski, Zheng Xing, Madeline M. McGinnis, Olga V. Hunter, Kyah M. Featherston, Komal Sethia, Benjamin P. Tu, Kate D. Meyer, Nicholas K. Conrad
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007375
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