A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic l...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/6971027 |
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| author | Abdullateef Abdulkareem Ryan S. D’Souza Oluwaseun Shogbesan Anthony Donato |
| author_facet | Abdullateef Abdulkareem Ryan S. D’Souza Oluwaseun Shogbesan Anthony Donato |
| author_sort | Abdullateef Abdulkareem |
| collection | DOAJ |
| description | Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy. |
| format | Article |
| id | doaj-art-0602b16b148d440291998face4962683 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-0602b16b148d440291998face49626832025-02-03T01:22:51ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/69710276971027A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the LiteratureAbdullateef Abdulkareem0Ryan S. D’Souza1Oluwaseun Shogbesan2Anthony Donato3Department of Medicine, Reading Hospital, West Reading, PA, USADepartment of Medicine, Reading Hospital, West Reading, PA, USADepartment of Medicine, Reading Hospital, West Reading, PA, USADepartment of Medicine, Reading Hospital, West Reading, PA, USANecrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.http://dx.doi.org/10.1155/2017/6971027 |
| spellingShingle | Abdullateef Abdulkareem Ryan S. D’Souza Oluwaseun Shogbesan Anthony Donato A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature Case Reports in Hematology |
| title | A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature |
| title_full | A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature |
| title_fullStr | A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature |
| title_full_unstemmed | A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature |
| title_short | A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature |
| title_sort | case of rituximab induced necrotizing fasciitis and a review of the literature |
| url | http://dx.doi.org/10.1155/2017/6971027 |
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