Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model

Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model

IntroductionMarfan Syndrome (MFS) is a connective tissue disorder due to mutations in fibrillin-1 (Fbn1), where a Fbn1 missense mutation (Fbn1C1039G/+) can result in systemic increases in the bioavailability and signaling of transforming growth factor-β (TGF-β). In a well-established mouse model of...

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Bibliographic Details
Main Authors: Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Theresa Currier Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Physiology
Subjects:
Marfan syndrome
microvascular density
blood-brain barrier
neuroinflammation
neuropathology
premature aging
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1457034/full
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