Microscopic methods in analysis of submicron phospholipid dispersions
Microscopy belongs to the group of tests, used in pharmaceutical technology, that despite the lapse of time and the development of new analytical methods, still remain irreplaceable for the characterization of dispersed drug dosage forms (e.g., suspensions and emulsions). To obtain complete descript...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0003 |
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| author | Płaczek Marcin Kosela Magdalena |
| author_facet | Płaczek Marcin Kosela Magdalena |
| author_sort | Płaczek Marcin |
| collection | DOAJ |
| description | Microscopy belongs to the group of tests, used in pharmaceutical technology, that despite the lapse of time and the development of new analytical methods, still remain irreplaceable for the characterization of dispersed drug dosage forms (e.g., suspensions and emulsions). To obtain complete description of a specific drug formulation, such as parenteral colloidal products, a combination of different microscopic techniques is sometimes required. Electron microscopy methods are the most useful ones; however, even such basic methods as optical microscopy may be helpful for determination of some properties of a sample. The publication explicates the most popular microscopical techniques used nowadays for characterization of the morphology of nanoparticles suspended in pharmaceutical formulations; ad vantages and disadvantages of these methods are also discussed. Parenteral submicron formulations containing lecithin or a particular phospholipid were chosen as examples. |
| format | Article |
| id | doaj-art-05f91138c7504207b8e9fc4f24f75af3 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-05f91138c7504207b8e9fc4f24f75af32025-02-02T09:55:40ZengSciendoActa Pharmaceutica1846-95582016-03-0166112210.1515/acph-2016-0003acph-2016-0003Microscopic methods in analysis of submicron phospholipid dispersionsPłaczek Marcin0Kosela Magdalena1Department of Pharmaceutical Technology, Medical University of Gdańsk, PolandDepartment of Pharmaceutical Technology, Medical University of Gdańsk, PolandMicroscopy belongs to the group of tests, used in pharmaceutical technology, that despite the lapse of time and the development of new analytical methods, still remain irreplaceable for the characterization of dispersed drug dosage forms (e.g., suspensions and emulsions). To obtain complete description of a specific drug formulation, such as parenteral colloidal products, a combination of different microscopic techniques is sometimes required. Electron microscopy methods are the most useful ones; however, even such basic methods as optical microscopy may be helpful for determination of some properties of a sample. The publication explicates the most popular microscopical techniques used nowadays for characterization of the morphology of nanoparticles suspended in pharmaceutical formulations; ad vantages and disadvantages of these methods are also discussed. Parenteral submicron formulations containing lecithin or a particular phospholipid were chosen as examples.https://doi.org/10.1515/acph-2016-0003optical microscopyelectron microscopyafmphospholipid dispersionsparenteral drug delivery systems |
| spellingShingle | Płaczek Marcin Kosela Magdalena Microscopic methods in analysis of submicron phospholipid dispersions Acta Pharmaceutica optical microscopy electron microscopy afm phospholipid dispersions parenteral drug delivery systems |
| title | Microscopic methods in analysis of submicron phospholipid dispersions |
| title_full | Microscopic methods in analysis of submicron phospholipid dispersions |
| title_fullStr | Microscopic methods in analysis of submicron phospholipid dispersions |
| title_full_unstemmed | Microscopic methods in analysis of submicron phospholipid dispersions |
| title_short | Microscopic methods in analysis of submicron phospholipid dispersions |
| title_sort | microscopic methods in analysis of submicron phospholipid dispersions |
| topic | optical microscopy electron microscopy afm phospholipid dispersions parenteral drug delivery systems |
| url | https://doi.org/10.1515/acph-2016-0003 |
| work_keys_str_mv | AT płaczekmarcin microscopicmethodsinanalysisofsubmicronphospholipiddispersions AT koselamagdalena microscopicmethodsinanalysisofsubmicronphospholipiddispersions |