Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma
Osteosarcoma is a kind of primary malignant tumor of bone. In recent years, its therapeutic effect and prognostic survival are dissatisfactory. The tumor immune microenvironment (TIME) reflects immune status of patients, but it is little known in osteosarcoma. Therefore, this study attempts to condu...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/2181525 |
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| _version_ | 1832548583943962624 |
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| author | Shunhan Yao Meiling Deng Xiaojing Du Qingfeng Chen Rongzhi Huang |
| author_facet | Shunhan Yao Meiling Deng Xiaojing Du Qingfeng Chen Rongzhi Huang |
| author_sort | Shunhan Yao |
| collection | DOAJ |
| description | Osteosarcoma is a kind of primary malignant tumor of bone. In recent years, its therapeutic effect and prognostic survival are dissatisfactory. The tumor immune microenvironment (TIME) reflects immune status of patients, but it is little known in osteosarcoma. Therefore, this study attempts to conduct a comprehensive analysis to explore TIME of osteosarcoma and identify TIME-related subtypes for clinical management and treatment. We successfully established two novel tumor immune infiltration clusters (TIIC) which are characterized by difference of microenvironment and immune-related biological processes. High tumor immune infiltration cluster (H-TIIC) subtypes with higher immune infiltration score shows a better overall survival. Further, the two immune subtypes are shown to differ in immunotherapy and chemotherapy. The results would be helpful for clinical decision in osteosarcoma. |
| format | Article |
| id | doaj-art-05d9eb7866e642b3abedf54689965b35 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-05d9eb7866e642b3abedf54689965b352025-02-03T06:13:35ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/2181525Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in OsteosarcomaShunhan Yao0Meiling Deng1Xiaojing Du2Qingfeng Chen3Rongzhi Huang4Medical CollegeSchool of Information and ManagementSchool of ComputerSchool of ComputerTraumatic Orthopedic Hand SurgeryOsteosarcoma is a kind of primary malignant tumor of bone. In recent years, its therapeutic effect and prognostic survival are dissatisfactory. The tumor immune microenvironment (TIME) reflects immune status of patients, but it is little known in osteosarcoma. Therefore, this study attempts to conduct a comprehensive analysis to explore TIME of osteosarcoma and identify TIME-related subtypes for clinical management and treatment. We successfully established two novel tumor immune infiltration clusters (TIIC) which are characterized by difference of microenvironment and immune-related biological processes. High tumor immune infiltration cluster (H-TIIC) subtypes with higher immune infiltration score shows a better overall survival. Further, the two immune subtypes are shown to differ in immunotherapy and chemotherapy. The results would be helpful for clinical decision in osteosarcoma.http://dx.doi.org/10.1155/2022/2181525 |
| spellingShingle | Shunhan Yao Meiling Deng Xiaojing Du Qingfeng Chen Rongzhi Huang Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma Journal of Immunology Research |
| title | Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma |
| title_full | Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma |
| title_fullStr | Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma |
| title_full_unstemmed | Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma |
| title_short | Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma |
| title_sort | identification of two novel immune subtypes characterized by distinct prognosis and tumor microenvironment in osteosarcoma |
| url | http://dx.doi.org/10.1155/2022/2181525 |
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