Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth

Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth

Background: Pyroptosis, a form of programmed cell death, has been shown to induce anti-tumour immunity and inhibit tumour growth. Oral squamous cell carcinoma (OSCC), a prevalent malignant tumour, could benefit from pyroptosis induction as a therapeutic strategy. Cucurbitacin B (CuB), a natural comp...

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Bibliographic Details
Main Authors: Xin Chen, Mengyuan Yang, Heng Zhang, Yajun Wang, Wenpeng Yan, Chen Cheng, Rongrong Guo, Jiawei Chai, YaHsin Zheng, Fang Zhang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Translational Oncology
Subjects:
Cucurbitacin B
GSDME
OSCC
pyroptosis
CD8+T
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001536
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