Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates
In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading ca...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2022/6353909 |
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| author | Sergei Y. Lipaikin Ivan A. Yaremenko Alexander O. Terent’ev Tatiana G. Volova Ekaterina I. Shishatskaya |
| author_facet | Sergei Y. Lipaikin Ivan A. Yaremenko Alexander O. Terent’ev Tatiana G. Volova Ekaterina I. Shishatskaya |
| author_sort | Sergei Y. Lipaikin |
| collection | DOAJ |
| description | In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems. |
| format | Article |
| id | doaj-art-05bb6da48d3c4e918a13445f40da672a |
| institution | Kabale University |
| issn | 1098-2329 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-05bb6da48d3c4e918a13445f40da672a2025-02-03T01:29:53ZengWileyAdvances in Polymer Technology1098-23292022-01-01202210.1155/2022/6353909Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial PolyhydroxyalkanoatesSergei Y. Lipaikin0Ivan A. Yaremenko1Alexander O. Terent’ev2Tatiana G. Volova3Ekaterina I. Shishatskaya4Siberian Federal UniversityN.D. Zelinsky Institute of Organic ChemistryN.D. Zelinsky Institute of Organic ChemistrySiberian Federal UniversitySiberian Federal UniversityIn this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems.http://dx.doi.org/10.1155/2022/6353909 |
| spellingShingle | Sergei Y. Lipaikin Ivan A. Yaremenko Alexander O. Terent’ev Tatiana G. Volova Ekaterina I. Shishatskaya Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates Advances in Polymer Technology |
| title | Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates |
| title_full | Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates |
| title_fullStr | Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates |
| title_full_unstemmed | Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates |
| title_short | Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates |
| title_sort | development of biodegradable delivery systems containing novel 1 2 4 trioxolane based on bacterial polyhydroxyalkanoates |
| url | http://dx.doi.org/10.1155/2022/6353909 |
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