An effective electrochemical sensor for monitoring tamoxifen as breast cancer medicine in biological samples using polypyrrole-based molecularly imprinted polymers and CNTs hybrid structure

An effective electrochemical sensor for monitoring tamoxifen as breast cancer medicine in biological samples using polypyrrole-based molecularly imprinted polymers and CNTs hybrid structure

This work was conducted on the development and characterization of a novel electrochemical sensor using polypyrrole-based molecularly imprinted polymer and CNTs hybrid-modified glassy carbon electrode (MIP/CNTs/GCE) for the determination of tamoxifen (TMX), a widely used breast cancer medicine, in b...

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Bibliographic Details
Main Authors: Junwei Chen, Zhaoyu Chen, Yucheng Zheng, Wenying Chen, Qingjun Zhu, Peng Sun, Yao Chen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Sensing and Bio-Sensing Research
Subjects:
Tamoxifen
Breast cancer
Carbon nanotubes
Polypyrrole
Molecularly imprinted polymer
Electrochemical sensor
Online Access:http://www.sciencedirect.com/science/article/pii/S2214180425000844
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Summary:This work was conducted on the development and characterization of a novel electrochemical sensor using polypyrrole-based molecularly imprinted polymer and CNTs hybrid-modified glassy carbon electrode (MIP/CNTs/GCE) for the determination of tamoxifen (TMX), a widely used breast cancer medicine, in biological samples. Characterization of the synthesized nanostructures using structural and morphological analyses confirmed the successful use of the MIP/CNTs hybrid and provided insights into the scaffolds' chemical and structural characteristics. Electrochemical analyses showed the enhanced performance of the MIP/CNTs/GCE sensor, which displayed a linear response range of 1 to 420 μM, sensitivity of 0.72337 μA/μM, and a detection limit of 0.01 μM for TMX. Reproducibility investigation exhibited an RSD of 2.96 %, and storage stability studies demonstrated that the electrochemical sensor retained 96.82 % of its initial response after 40 days. Moreover, the MIP sensor showed great selectivity for TMX in the presence of potential interferents and received recovery rates of 98.20 % to 99.10 % in human serum specimens. The findings show that the designed MIP/CNTs/GCE sensor can monitor TMX in complicated biological matrices in a reliable and effective manner.
ISSN:2214-1804

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