Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer
Peroxisome proliferator-activated receptor-𝛾 (PPAR)-𝛾 is a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR-𝛾 plays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR-𝛾 is expressed in various cancer tissues, and PPAR-𝛾 ligand induces...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/249849 |
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| author | Masahide Matsuyama Rikio Yoshimura |
| author_facet | Masahide Matsuyama Rikio Yoshimura |
| author_sort | Masahide Matsuyama |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-𝛾 (PPAR)-𝛾 is a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR-𝛾 plays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR-𝛾 is expressed in various cancer tissues, and PPAR-𝛾 ligand induces growth arrest of these cancer cells. In this study, we examined the expression of PPAR-𝛾 in prostate cancer (PC) and testicular cancer (TC) by RT-PCR and immunohistochemistry, and we also examined the effect of PPAR-𝛾 ligand in these cells by MTT assay, hoechest staining, and flow cytometry. PPAR-𝛾 expression was significantly more extensive and intense in malignant tissues than in normal tissues. PPAR-𝛾 ligand induced the reduction of malignant cell viability through apoptosis. These results demonstrated that the generated PPAR-𝛾 in PC and TC cells might play an important role in the tumorigenesis. PPAR-𝛾 may become a new target in the treatment of PC and TC. |
| format | Article |
| id | doaj-art-05b5b6d95c494128accdaa13a907f2ea |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-05b5b6d95c494128accdaa13a907f2ea2025-02-03T01:22:11ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/249849249849Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular CancerMasahide Matsuyama0Rikio Yoshimura1Department of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, JapanPeroxisome proliferator-activated receptor-𝛾 (PPAR)-𝛾 is a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR-𝛾 plays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR-𝛾 is expressed in various cancer tissues, and PPAR-𝛾 ligand induces growth arrest of these cancer cells. In this study, we examined the expression of PPAR-𝛾 in prostate cancer (PC) and testicular cancer (TC) by RT-PCR and immunohistochemistry, and we also examined the effect of PPAR-𝛾 ligand in these cells by MTT assay, hoechest staining, and flow cytometry. PPAR-𝛾 expression was significantly more extensive and intense in malignant tissues than in normal tissues. PPAR-𝛾 ligand induced the reduction of malignant cell viability through apoptosis. These results demonstrated that the generated PPAR-𝛾 in PC and TC cells might play an important role in the tumorigenesis. PPAR-𝛾 may become a new target in the treatment of PC and TC.http://dx.doi.org/10.1155/2008/249849 |
| spellingShingle | Masahide Matsuyama Rikio Yoshimura Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer PPAR Research |
| title | Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in
Human Prostate and Testicular Cancer |
| title_full | Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in
Human Prostate and Testicular Cancer |
| title_fullStr | Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in
Human Prostate and Testicular Cancer |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in
Human Prostate and Testicular Cancer |
| title_short | Peroxisome Proliferator-Activated Receptor-𝛾 Is a Potent Target for Prevention and Treatment in
Human Prostate and Testicular Cancer |
| title_sort | peroxisome proliferator activated receptor 𝛾 is a potent target for prevention and treatment in human prostate and testicular cancer |
| url | http://dx.doi.org/10.1155/2008/249849 |
| work_keys_str_mv | AT masahidematsuyama peroxisomeproliferatoractivatedreceptorγisapotenttargetforpreventionandtreatmentinhumanprostateandtesticularcancer AT rikioyoshimura peroxisomeproliferatoractivatedreceptorγisapotenttargetforpreventionandtreatmentinhumanprostateandtesticularcancer |