The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27,...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/269541 |
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| author | Joanna Narbutt Aleksandra Lesiak Anna Sysa-Jedrzeiowska Marcin Zakrzewski Jarosław Bogaczewicz Iwona Stelmach Piotr Kuna |
| author_facet | Joanna Narbutt Aleksandra Lesiak Anna Sysa-Jedrzeiowska Marcin Zakrzewski Jarosław Bogaczewicz Iwona Stelmach Piotr Kuna |
| author_sort | Joanna Narbutt |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is an inflammatory skin
disease in which pathogenesis chemokines are
partially involved. The aim of the paper was to
assess the serum level of CXCL-9, CXCL-10, CXCL-11,
CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and
IL-18 chosen in AD patients by ELISA assay. Forty
patients (mean age 11.4 years old) with AD and 50
healthy controls were enrolled into the study. The
patients and controls were divided into two age
categories: under 10 years old (Group 1 and Control 1)
and over 10 years old (Group 2 and Control 2).
Significantly lower serum concentration of CXCL-9,
CXCL-10, CCL-17, and IL-18 and higher concentration
of CXCL-12 and CCL-27 were found in Group 1 when
compared to Control 1. In Group 2 serum
concentration of CXCL-12, CCL-17, CCL-22 was higher
than in Control 2. The obtained results indicate the
imbalance in chemokine serum levels in AD what
suggests their role in the disease pathogenesis. |
| format | Article |
| id | doaj-art-05ac944b8c6e43a78d0692b425f68f08 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-05ac944b8c6e43a78d0692b425f68f082025-02-03T01:27:11ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/269541269541The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic DermatitisJoanna Narbutt0Aleksandra Lesiak1Anna Sysa-Jedrzeiowska2Marcin Zakrzewski3Jarosław Bogaczewicz4Iwona Stelmach5Piotr Kuna6Department of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Pediatrics and Allergy, Medical University of Lodz, 90-153 Lodz, PolandDivision of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 93-036 Lodz, PolandAtopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and IL-18 chosen in AD patients by ELISA assay. Forty patients (mean age 11.4 years old) with AD and 50 healthy controls were enrolled into the study. The patients and controls were divided into two age categories: under 10 years old (Group 1 and Control 1) and over 10 years old (Group 2 and Control 2). Significantly lower serum concentration of CXCL-9, CXCL-10, CCL-17, and IL-18 and higher concentration of CXCL-12 and CCL-27 were found in Group 1 when compared to Control 1. In Group 2 serum concentration of CXCL-12, CCL-17, CCL-22 was higher than in Control 2. The obtained results indicate the imbalance in chemokine serum levels in AD what suggests their role in the disease pathogenesis.http://dx.doi.org/10.1155/2009/269541 |
| spellingShingle | Joanna Narbutt Aleksandra Lesiak Anna Sysa-Jedrzeiowska Marcin Zakrzewski Jarosław Bogaczewicz Iwona Stelmach Piotr Kuna The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis Mediators of Inflammation |
| title | The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis |
| title_full | The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis |
| title_fullStr | The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis |
| title_full_unstemmed | The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis |
| title_short | The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis |
| title_sort | imbalance in serum concentration of th 1 and th 2 derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis |
| url | http://dx.doi.org/10.1155/2009/269541 |
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