Genetic influence on choroidal vascularity index.
<h4>Purpose</h4>To investigate the heritability of genetic influence on macular choroidal vascularity index (CVI).<h4>Methods</h4>Total choroidal area (TCA), luminal area (LA), and CVI was measured using horizontal scan of spectral-domain optical coherence tomography with enh...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0318369 |
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| author | Je Moon Yoon Yong Jin Gil Joohon Sung Don-Il Ham Mingui Kong |
| author_facet | Je Moon Yoon Yong Jin Gil Joohon Sung Don-Il Ham Mingui Kong |
| author_sort | Je Moon Yoon |
| collection | DOAJ |
| description | <h4>Purpose</h4>To investigate the heritability of genetic influence on macular choroidal vascularity index (CVI).<h4>Methods</h4>Total choroidal area (TCA), luminal area (LA), and CVI was measured using horizontal scan of spectral-domain optical coherence tomography with enhanced depth imaging in the 373 healthy twin participants. Characteristics of the participants were investigated, including age, sex, axial length, hypertension, diabetes, drinking habits, and smoking status. Univariate and subsequent multivariate regression analyses were performed to evaluate the associations of these factors with TCA, LA, and CVI.<h4>Results</h4>Patients who were older and had a higher intraocular pressure, higher diastolic blood pressure, and lower pulse pressure showed associations with lower CVI (p<0.001, p = 0.014, p = 0.005, and p = 0.015, respectively). The covariate-adjusted heritability (±standard error) of the CVI was 0.716 ± 0.091, and the heritabilities of the TCA and LA were 0.691 ± 0.089 and 0.634 ± 0.100, respectively.<h4>Conclusion</h4>The TCA, LA, and CVI are highly heritable. |
| format | Article |
| id | doaj-art-05a824df70ee4063b53df7014f0f5105 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-05a824df70ee4063b53df7014f0f51052025-02-05T05:31:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031836910.1371/journal.pone.0318369Genetic influence on choroidal vascularity index.Je Moon YoonYong Jin GilJoohon SungDon-Il HamMingui Kong<h4>Purpose</h4>To investigate the heritability of genetic influence on macular choroidal vascularity index (CVI).<h4>Methods</h4>Total choroidal area (TCA), luminal area (LA), and CVI was measured using horizontal scan of spectral-domain optical coherence tomography with enhanced depth imaging in the 373 healthy twin participants. Characteristics of the participants were investigated, including age, sex, axial length, hypertension, diabetes, drinking habits, and smoking status. Univariate and subsequent multivariate regression analyses were performed to evaluate the associations of these factors with TCA, LA, and CVI.<h4>Results</h4>Patients who were older and had a higher intraocular pressure, higher diastolic blood pressure, and lower pulse pressure showed associations with lower CVI (p<0.001, p = 0.014, p = 0.005, and p = 0.015, respectively). The covariate-adjusted heritability (±standard error) of the CVI was 0.716 ± 0.091, and the heritabilities of the TCA and LA were 0.691 ± 0.089 and 0.634 ± 0.100, respectively.<h4>Conclusion</h4>The TCA, LA, and CVI are highly heritable.https://doi.org/10.1371/journal.pone.0318369 |
| spellingShingle | Je Moon Yoon Yong Jin Gil Joohon Sung Don-Il Ham Mingui Kong Genetic influence on choroidal vascularity index. PLoS ONE |
| title | Genetic influence on choroidal vascularity index. |
| title_full | Genetic influence on choroidal vascularity index. |
| title_fullStr | Genetic influence on choroidal vascularity index. |
| title_full_unstemmed | Genetic influence on choroidal vascularity index. |
| title_short | Genetic influence on choroidal vascularity index. |
| title_sort | genetic influence on choroidal vascularity index |
| url | https://doi.org/10.1371/journal.pone.0318369 |
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