Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature
Hairy cell leukemia/lymphoma (HCL) is a rare B-cell neoplasm primarily involving spleen, bone marrow, and blood. However, other sites of primary involvement do occur and can present a diagnostic and therapeutic challenge. We present an unusual case of HCL involving predominantly the breast that was...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/497027 |
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| author | Monika Pilichowska Ahmad Shariftabrizi Ian Mukand-Cerro Kenneth Miller |
| author_facet | Monika Pilichowska Ahmad Shariftabrizi Ian Mukand-Cerro Kenneth Miller |
| author_sort | Monika Pilichowska |
| collection | DOAJ |
| description | Hairy cell leukemia/lymphoma (HCL) is a rare B-cell neoplasm primarily involving spleen, bone marrow, and blood. However, other sites of primary involvement do occur and can present a diagnostic and therapeutic challenge. We present an unusual case of HCL involving predominantly the breast that was diagnosed as an incidental finding during an elective reduction mammoplasty in an otherwise healthy asymptomatic woman. Bone marrow performed for staging revealed limited involvement by HCL. Notably, there was no splenomegaly and/or involvement of other extramedullary sites. The peripheral blood revealed minimal involvement detected by flow cytometry. Extensive immunohistochemical studies supported by positive BRAF V600E mutational status confirmed the diagnosis of HCL. The patient remains asymptomatic without treatment one year following the diagnosis. This is the first case of a well-documented HCL presenting primarily in the breast in an asymptomatic patient. We review the literature on extramedullary, extrasplenic involvement by HCL and discuss the diagnostic challenges as well as the utility of immunohistochemistry and molecular studies in the diagnosis of atypical presentations of HCL. |
| format | Article |
| id | doaj-art-05a2929f8bcf4d9b98b6a9bde6257f63 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-05a2929f8bcf4d9b98b6a9bde6257f632025-02-03T01:11:17ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/497027497027Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the LiteratureMonika Pilichowska0Ahmad Shariftabrizi1Ian Mukand-Cerro2Kenneth Miller3Department of Pathology and Laboratory Medicine and Department of Hematology-Oncology, Tufts Medical Center, Tufts University Medical School, Washington Street 800, Boston, MA 02111, USADepartment of Pathology and Laboratory Medicine and Department of Hematology-Oncology, Tufts Medical Center, Tufts University Medical School, Washington Street 800, Boston, MA 02111, USADepartment of Pathology and Laboratory Medicine and Department of Hematology-Oncology, Tufts Medical Center, Tufts University Medical School, Washington Street 800, Boston, MA 02111, USADepartment of Pathology and Laboratory Medicine and Department of Hematology-Oncology, Tufts Medical Center, Tufts University Medical School, Washington Street 800, Boston, MA 02111, USAHairy cell leukemia/lymphoma (HCL) is a rare B-cell neoplasm primarily involving spleen, bone marrow, and blood. However, other sites of primary involvement do occur and can present a diagnostic and therapeutic challenge. We present an unusual case of HCL involving predominantly the breast that was diagnosed as an incidental finding during an elective reduction mammoplasty in an otherwise healthy asymptomatic woman. Bone marrow performed for staging revealed limited involvement by HCL. Notably, there was no splenomegaly and/or involvement of other extramedullary sites. The peripheral blood revealed minimal involvement detected by flow cytometry. Extensive immunohistochemical studies supported by positive BRAF V600E mutational status confirmed the diagnosis of HCL. The patient remains asymptomatic without treatment one year following the diagnosis. This is the first case of a well-documented HCL presenting primarily in the breast in an asymptomatic patient. We review the literature on extramedullary, extrasplenic involvement by HCL and discuss the diagnostic challenges as well as the utility of immunohistochemistry and molecular studies in the diagnosis of atypical presentations of HCL.http://dx.doi.org/10.1155/2014/497027 |
| spellingShingle | Monika Pilichowska Ahmad Shariftabrizi Ian Mukand-Cerro Kenneth Miller Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature Case Reports in Pathology |
| title | Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature |
| title_full | Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature |
| title_fullStr | Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature |
| title_full_unstemmed | Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature |
| title_short | Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature |
| title_sort | primary hairy cell leukemia lymphoma of the breast a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2014/497027 |
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