Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study
Objectives: The use of complementary and alternative medicine (CAM) by patients with rheumatoid arthritis (RA) is highly prevalent. The relationship of these remedies with disease therapy are not fully studied. We aimed to explore the relationship between different anti-rheumatic drug therapy and CA...
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Springer
2021-05-01
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| Series: | Saudi Pharmaceutical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016421000669 |
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| author | Haya M. Almalag Aseel M. Almuhareb Aya A. Alsharafi Tariq M. Alhawassi Ahmed A. Alghamdi Hussain Alarfaj Mohammed A. Omair Bedor A. Alomari Maysoon S. Alblowi Hanan H. Abouzaid Abdurhman S. Alarfaj |
| author_facet | Haya M. Almalag Aseel M. Almuhareb Aya A. Alsharafi Tariq M. Alhawassi Ahmed A. Alghamdi Hussain Alarfaj Mohammed A. Omair Bedor A. Alomari Maysoon S. Alblowi Hanan H. Abouzaid Abdurhman S. Alarfaj |
| author_sort | Haya M. Almalag |
| collection | DOAJ |
| description | Objectives: The use of complementary and alternative medicine (CAM) by patients with rheumatoid arthritis (RA) is highly prevalent. The relationship of these remedies with disease therapy are not fully studied. We aimed to explore the relationship between different anti-rheumatic drug therapy and CAM use in RA patients. Methods: The study used an interview-based cross-sectional survey in two major referral centres in Riyadh, Saudi Arabia. Patients were adults with confirmed RA that attended rheumatology clinics. Information on the utilization of CAM, RA duration, drug therapy, and laboratory parameters were obtained. Descriptive statistics as well as adjusted odds ratio using bivariate logistic regression were used to explore the different factors related to CAM use, including drug therapy. Results: A total of 438 adult patients with RA were included. The mean (±SD) age of the patients was 49 (±15.0) years. The majority were women 393 (89.7%). Two hundred and ninety-two patients (66.7%) had used CAM. The CAM users who had a longer disease duration (AOR 1.041 [95% CI: 1.011, 1.073]; p = 0.008) were more likely to be female (AOR 2.068 [95% CI: 1.098, 3.896]; p = 0.024), and use methotrexate (AOR 1.918 [95% CI: 1.249, 2.946]; p = 0.003) as opposed to celecoxib (AOR 0.509 [95% CI: 0.307, 0.844]; p = 0.009) and biologic monotherapy (AOR 0.443 [95% CI: 0.224, 0.876]; p = 0.019). Other factors related to CAM were meloxicam use (AOR 2.342 [95% CI: 1.341, 4.089]; p = 0.003) and traditional therapy (AOR 2.989 [95% CI: 1.647, 5.425]; p = 0.000). The remaining factors were not significant. Conclusion: CAM use is prevalent in patients with RA. Understanding patients and disease related factors associated with higher use of CAM is warranted to improve RA management and provide more rational use of these remedies. |
| format | Article |
| id | doaj-art-059cad75ac7f4a9d8b9925f1978ce405 |
| institution | Kabale University |
| issn | 1319-0164 |
| language | English |
| publishDate | 2021-05-01 |
| publisher | Springer |
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| series | Saudi Pharmaceutical Journal |
| spelling | doaj-art-059cad75ac7f4a9d8b9925f1978ce4052025-08-20T03:54:28ZengSpringerSaudi Pharmaceutical Journal1319-01642021-05-0129546246610.1016/j.jsps.2021.04.009Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional studyHaya M. Almalag0Aseel M. Almuhareb1Aya A. Alsharafi2Tariq M. Alhawassi3Ahmed A. Alghamdi4Hussain Alarfaj5Mohammed A. Omair6Bedor A. Alomari7Maysoon S. Alblowi8Hanan H. Abouzaid9Abdurhman S. Alarfaj10Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Corresponding author at: Department of Clinical Pharmacy, King Saud University, College of Pharmacy, Riyadh 11149, Saudi Arabia.Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Clinical Pharmacy and Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaRheumatology Unit, Department of Medicine, King Saud University Medical City, Riyadh, Saudi ArabiaRheumatology Unit, Department of Medicine, King Saud University Medical City, Riyadh, Saudi ArabiaRheumatology Clinical Pharmacist, Department of Pharmaceutical Service, Prince Sultan Military Medical City, Riyadh, Saudi ArabiaRheumatology Unit, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaRheumatology Unit, Department of Medicine, King Saud University Medical City, Riyadh, Saudi ArabiaObjectives: The use of complementary and alternative medicine (CAM) by patients with rheumatoid arthritis (RA) is highly prevalent. The relationship of these remedies with disease therapy are not fully studied. We aimed to explore the relationship between different anti-rheumatic drug therapy and CAM use in RA patients. Methods: The study used an interview-based cross-sectional survey in two major referral centres in Riyadh, Saudi Arabia. Patients were adults with confirmed RA that attended rheumatology clinics. Information on the utilization of CAM, RA duration, drug therapy, and laboratory parameters were obtained. Descriptive statistics as well as adjusted odds ratio using bivariate logistic regression were used to explore the different factors related to CAM use, including drug therapy. Results: A total of 438 adult patients with RA were included. The mean (±SD) age of the patients was 49 (±15.0) years. The majority were women 393 (89.7%). Two hundred and ninety-two patients (66.7%) had used CAM. The CAM users who had a longer disease duration (AOR 1.041 [95% CI: 1.011, 1.073]; p = 0.008) were more likely to be female (AOR 2.068 [95% CI: 1.098, 3.896]; p = 0.024), and use methotrexate (AOR 1.918 [95% CI: 1.249, 2.946]; p = 0.003) as opposed to celecoxib (AOR 0.509 [95% CI: 0.307, 0.844]; p = 0.009) and biologic monotherapy (AOR 0.443 [95% CI: 0.224, 0.876]; p = 0.019). Other factors related to CAM were meloxicam use (AOR 2.342 [95% CI: 1.341, 4.089]; p = 0.003) and traditional therapy (AOR 2.989 [95% CI: 1.647, 5.425]; p = 0.000). The remaining factors were not significant. Conclusion: CAM use is prevalent in patients with RA. Understanding patients and disease related factors associated with higher use of CAM is warranted to improve RA management and provide more rational use of these remedies.http://www.sciencedirect.com/science/article/pii/S1319016421000669Chronic illnessRheumatoid arthritisCAM practicesAnti-rheumatic therapiesPatient safetyDisease activity |
| spellingShingle | Haya M. Almalag Aseel M. Almuhareb Aya A. Alsharafi Tariq M. Alhawassi Ahmed A. Alghamdi Hussain Alarfaj Mohammed A. Omair Bedor A. Alomari Maysoon S. Alblowi Hanan H. Abouzaid Abdurhman S. Alarfaj Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study Saudi Pharmaceutical Journal Chronic illness Rheumatoid arthritis CAM practices Anti-rheumatic therapies Patient safety Disease activity |
| title | Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study |
| title_full | Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study |
| title_fullStr | Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study |
| title_full_unstemmed | Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study |
| title_short | Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study |
| title_sort | relationship between different anti rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis an interview based cross sectional study |
| topic | Chronic illness Rheumatoid arthritis CAM practices Anti-rheumatic therapies Patient safety Disease activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319016421000669 |
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