A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis
Some patients with severe fever with thrombocytopenia syndrome (SFTS) develop complications including viral encephalitis and fungal infections, with a mortality rate reaching 44.7 %. In this case, the patient was admitted on Day 5 of illness, with symptoms of apathy and a delayed response. Computed...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925002033 |
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| author | Dan Li Hongyan Liu Yan Wang Wei Guo Hua Wen Junyan Yang Qingquan Dai Siqi Jia Jiaxiang Zhang |
| author_facet | Dan Li Hongyan Liu Yan Wang Wei Guo Hua Wen Junyan Yang Qingquan Dai Siqi Jia Jiaxiang Zhang |
| author_sort | Dan Li |
| collection | DOAJ |
| description | Some patients with severe fever with thrombocytopenia syndrome (SFTS) develop complications including viral encephalitis and fungal infections, with a mortality rate reaching 44.7 %. In this case, the patient was admitted on Day 5 of illness, with symptoms of apathy and a delayed response. Computed tomography (CT) scans of the head and lungs revealed no abnormalities. After admission, the patient was diagnosed with SFTS. Following treatment, the patient's body temperature returned to normal, and laboratory tests revealed increased white blood cell and platelet counts and decreased myocardial enzymes. However, on Day 10 of illness, the patient experienced convulsions and somnolence. Enhanced brain magnetic resonance imaging (MRI) revealed multiple nodular abnormal signal shadows in the skull. Cerebrospinal fluid metagenomic sequencing revealed Aspergillus fumigatus infection. The patient also developed respiratory symptoms, and a chest CT revealed inflammatory changes. As the patient was suspected to have both intracranial and pulmonary Aspergillus infections, antifungal treatment was initiated. The patient's condition gradually improved with antifungal therapy, and the patient is currently receiving oral treatment with isavuconazole. |
| format | Article |
| id | doaj-art-05939a018d9443afa5cea46a9f787d2d |
| institution | Kabale University |
| issn | 2214-2509 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj-art-05939a018d9443afa5cea46a9f787d2d2025-08-20T05:06:53ZengElsevierIDCases2214-25092025-01-0141e0234710.1016/j.idcr.2025.e02347A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosisDan Li0Hongyan Liu1Yan Wang2Wei Guo3Hua Wen4Junyan Yang5Qingquan Dai6Siqi Jia7Jiaxiang Zhang8Department of Infection Diseases, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Infection Diseases, The Sixth People's Hospital of Shenyang, Shenyang, China; Corresponding author.Department of Infection Diseases, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Infection Diseases, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Neurosurgery, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Radiology, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Infection Diseases, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Infection Diseases, The Sixth People's Hospital of Shenyang, Shenyang, ChinaDepartment of Neurosurgery, The Sixth People's Hospital of Shenyang, Shenyang, ChinaSome patients with severe fever with thrombocytopenia syndrome (SFTS) develop complications including viral encephalitis and fungal infections, with a mortality rate reaching 44.7 %. In this case, the patient was admitted on Day 5 of illness, with symptoms of apathy and a delayed response. Computed tomography (CT) scans of the head and lungs revealed no abnormalities. After admission, the patient was diagnosed with SFTS. Following treatment, the patient's body temperature returned to normal, and laboratory tests revealed increased white blood cell and platelet counts and decreased myocardial enzymes. However, on Day 10 of illness, the patient experienced convulsions and somnolence. Enhanced brain magnetic resonance imaging (MRI) revealed multiple nodular abnormal signal shadows in the skull. Cerebrospinal fluid metagenomic sequencing revealed Aspergillus fumigatus infection. The patient also developed respiratory symptoms, and a chest CT revealed inflammatory changes. As the patient was suspected to have both intracranial and pulmonary Aspergillus infections, antifungal treatment was initiated. The patient's condition gradually improved with antifungal therapy, and the patient is currently receiving oral treatment with isavuconazole.http://www.sciencedirect.com/science/article/pii/S2214250925002033SFTSIntracranial infectionFungal infectionInvasive pulmonary aspergillosisPrognosis |
| spellingShingle | Dan Li Hongyan Liu Yan Wang Wei Guo Hua Wen Junyan Yang Qingquan Dai Siqi Jia Jiaxiang Zhang A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis IDCases SFTS Intracranial infection Fungal infection Invasive pulmonary aspergillosis Prognosis |
| title | A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis |
| title_full | A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis |
| title_fullStr | A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis |
| title_full_unstemmed | A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis |
| title_short | A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis |
| title_sort | patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis |
| topic | SFTS Intracranial infection Fungal infection Invasive pulmonary aspergillosis Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214250925002033 |
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