A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis
Some patients with severe fever with thrombocytopenia syndrome (SFTS) develop complications including viral encephalitis and fungal infections, with a mortality rate reaching 44.7 %. In this case, the patient was admitted on Day 5 of illness, with symptoms of apathy and a delayed response. Computed...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925002033 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Some patients with severe fever with thrombocytopenia syndrome (SFTS) develop complications including viral encephalitis and fungal infections, with a mortality rate reaching 44.7 %. In this case, the patient was admitted on Day 5 of illness, with symptoms of apathy and a delayed response. Computed tomography (CT) scans of the head and lungs revealed no abnormalities. After admission, the patient was diagnosed with SFTS. Following treatment, the patient's body temperature returned to normal, and laboratory tests revealed increased white blood cell and platelet counts and decreased myocardial enzymes. However, on Day 10 of illness, the patient experienced convulsions and somnolence. Enhanced brain magnetic resonance imaging (MRI) revealed multiple nodular abnormal signal shadows in the skull. Cerebrospinal fluid metagenomic sequencing revealed Aspergillus fumigatus infection. The patient also developed respiratory symptoms, and a chest CT revealed inflammatory changes. As the patient was suspected to have both intracranial and pulmonary Aspergillus infections, antifungal treatment was initiated. The patient's condition gradually improved with antifungal therapy, and the patient is currently receiving oral treatment with isavuconazole. |
|---|---|
| ISSN: | 2214-2509 |