Targeting the PI3K-AKT pathway to alleviate 6PPDQ-induced cognitive impairment associated with metabolic syndrome

Targeting the PI3K-AKT pathway to alleviate 6PPDQ-induced cognitive impairment associated with metabolic syndrome

6PPD-quinone (6PPDQ), a derivative of the antioxidant 6PPD used in the rubber industry, has been implicated in environmental and public health risks. To explore its impact on metabolic and cognitive functions, we orally administered 6PPDQ to mice and assessed its effects. Our results show that 6PPDQ...

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Bibliographic Details
Main Authors: Leisheng Wang, Yifei Fu, Shiwei Xu, Enhong Chen, Shuo Zhang, Dongjie Yang, Youzhao He, Yuanlong Gu, Yong Mao, Fenglai Yuan, Hao Hu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
6PPD-quinone
Metabolic syndrome
Cognitive impairment
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325010565
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