Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review
Although recent advances in novel treatment approaches and therapeutics have shifted the treatment landscape of multiple myeloma, it remains an incurable plasma cell malignancy. Growing knowledge of the genome and expressed genomic information characterizing the biologic behavior of multiple myeloma...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/6934183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554266473005056 |
|---|---|
| author | Taiga Nishihori Kenneth Shain |
| author_facet | Taiga Nishihori Kenneth Shain |
| author_sort | Taiga Nishihori |
| collection | DOAJ |
| description | Although recent advances in novel treatment approaches and therapeutics have shifted the treatment landscape of multiple myeloma, it remains an incurable plasma cell malignancy. Growing knowledge of the genome and expressed genomic information characterizing the biologic behavior of multiple myeloma continues to accumulate. However, translation and incorporation of vast molecular understanding of complex tumor biology to deliver personalized and precision treatment to cure multiple myeloma have not been successful to date. Our review focuses on current evidence and understanding of myeloma biology with characterization in the context of genomic and molecular alterations. We also discuss future clinical application of the genomic and molecular knowledge, and more translational research is needed to benefit our myeloma patients. |
| format | Article |
| id | doaj-art-0588eb907b81402fbe3088cd5e6cfda2 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-0588eb907b81402fbe3088cd5e6cfda22025-02-03T05:51:55ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/69341836934183Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical ReviewTaiga Nishihori0Kenneth Shain1Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USADepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USAAlthough recent advances in novel treatment approaches and therapeutics have shifted the treatment landscape of multiple myeloma, it remains an incurable plasma cell malignancy. Growing knowledge of the genome and expressed genomic information characterizing the biologic behavior of multiple myeloma continues to accumulate. However, translation and incorporation of vast molecular understanding of complex tumor biology to deliver personalized and precision treatment to cure multiple myeloma have not been successful to date. Our review focuses on current evidence and understanding of myeloma biology with characterization in the context of genomic and molecular alterations. We also discuss future clinical application of the genomic and molecular knowledge, and more translational research is needed to benefit our myeloma patients.http://dx.doi.org/10.1155/2017/6934183 |
| spellingShingle | Taiga Nishihori Kenneth Shain Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review International Journal of Genomics |
| title | Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review |
| title_full | Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review |
| title_fullStr | Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review |
| title_full_unstemmed | Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review |
| title_short | Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review |
| title_sort | insights on genomic and molecular alterations in multiple myeloma and their incorporation towards risk adapted treatment strategy concise clinical review |
| url | http://dx.doi.org/10.1155/2017/6934183 |
| work_keys_str_mv | AT taiganishihori insightsongenomicandmolecularalterationsinmultiplemyelomaandtheirincorporationtowardsriskadaptedtreatmentstrategyconciseclinicalreview AT kennethshain insightsongenomicandmolecularalterationsinmultiplemyelomaandtheirincorporationtowardsriskadaptedtreatmentstrategyconciseclinicalreview |