Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants
ObjectiveAbstinence time has been associated with semen quality, but the results remain controversial.MethodsThis study recruited 3052 men undergoing fertility evaluation. Abstinence time (AT) was categorized as short (0-1 day), WHO-recommended (2-7 days) and long (>7 days). Semen parameters...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1472333/full |
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| author | Guanying Yao Qinglin Qi Xianchao Dou Wen Zhou Shun Bai Xi Zhang Xi Zhang |
| author_facet | Guanying Yao Qinglin Qi Xianchao Dou Wen Zhou Shun Bai Xi Zhang Xi Zhang |
| author_sort | Guanying Yao |
| collection | DOAJ |
| description | ObjectiveAbstinence time has been associated with semen quality, but the results remain controversial.MethodsThis study recruited 3052 men undergoing fertility evaluation. Abstinence time (AT) was categorized as short (0-1 day), WHO-recommended (2-7 days) and long (>7 days). Semen parameters including volume, sperm concentration, progressive motility, total motility, total motility sperm count (TMSC), morphology and DNA fragmentation index were assessed for their association with AT.ResultsShort AT was significantly associated with lower semen volume (P< 0.001), sperm concentration (P= 0.01) and TMSC (P< 0.001), while long AT was significantly associated with higher sperm concentration (P= 0.006), reduced progressive motility (P= 0.005) and total motility (P= 0.02), and higher DFI (P< 0.001). Restricted cubic spline models demonstrated a non-linear relationship between AT and the risk of low semen volume (Pnon-linear < 0.001), sperm concentration (Pnon-linear = 0.039) and TMSC (Pnon-linear < 0.001).ConclusionsOur findings suggest both short and long AT were significantly associated with lower sperm quality, which indicated the importance of maintaining a recommended AT (2-7days) for semen analysis. Additionally, short abstinence periods may be recommended to maintain optimal sperm DNA integrity. |
| format | Article |
| id | doaj-art-05836e790d534b75b8145ed12905c8e5 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-05836e790d534b75b8145ed12905c8e52025-01-24T10:59:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.14723331472333Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participantsGuanying Yao0Qinglin Qi1Xianchao Dou2Wen Zhou3Shun Bai4Xi Zhang5Xi Zhang6Department of Reproductive Medicine, Nanyang Central Hospital, Nanyang, Henan, ChinaDepartment of Reproductive Health, Pingxiang Maternal and Child Health Hospital, Pingxiang, Jiangxi, ChinaSchool of Medical Imaging, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Reproductive Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, ChinaDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, ChinaKey Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, ChinaObjectiveAbstinence time has been associated with semen quality, but the results remain controversial.MethodsThis study recruited 3052 men undergoing fertility evaluation. Abstinence time (AT) was categorized as short (0-1 day), WHO-recommended (2-7 days) and long (>7 days). Semen parameters including volume, sperm concentration, progressive motility, total motility, total motility sperm count (TMSC), morphology and DNA fragmentation index were assessed for their association with AT.ResultsShort AT was significantly associated with lower semen volume (P< 0.001), sperm concentration (P= 0.01) and TMSC (P< 0.001), while long AT was significantly associated with higher sperm concentration (P= 0.006), reduced progressive motility (P= 0.005) and total motility (P= 0.02), and higher DFI (P< 0.001). Restricted cubic spline models demonstrated a non-linear relationship between AT and the risk of low semen volume (Pnon-linear < 0.001), sperm concentration (Pnon-linear = 0.039) and TMSC (Pnon-linear < 0.001).ConclusionsOur findings suggest both short and long AT were significantly associated with lower sperm quality, which indicated the importance of maintaining a recommended AT (2-7days) for semen analysis. Additionally, short abstinence periods may be recommended to maintain optimal sperm DNA integrity.https://www.frontiersin.org/articles/10.3389/fendo.2025.1472333/fullabstinence timesemen qualitysemen parametersDNA fragmentation indexDFI |
| spellingShingle | Guanying Yao Qinglin Qi Xianchao Dou Wen Zhou Shun Bai Xi Zhang Xi Zhang Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants Frontiers in Endocrinology abstinence time semen quality semen parameters DNA fragmentation index DFI |
| title | Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants |
| title_full | Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants |
| title_fullStr | Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants |
| title_full_unstemmed | Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants |
| title_short | Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants |
| title_sort | association of abstinence time with semen quality in men who undergoing fertility evaluation a cross sectional study from 3052 participants |
| topic | abstinence time semen quality semen parameters DNA fragmentation index DFI |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1472333/full |
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