A model of thermotherapy treatment for bladder cancer
In this work, we investigate chemo- thermotherapy, a recently clinically-approved post-surgery treatment of non muscle invasive urothelial bladder carcinoma. We developed a mathematical model and numerically simulated the physical processes related to this treatment. The model is based on the condu...
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| Format: | Article |
| Language: | English |
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AIMS Press
2016-07-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2016037 |
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| _version_ | 1832590024450768896 |
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| author | Christoph Sadée Eugene Kashdan |
| author_facet | Christoph Sadée Eugene Kashdan |
| author_sort | Christoph Sadée |
| collection | DOAJ |
| description | In this work, we investigate chemo- thermotherapy, a recently clinically-approved post-surgery treatment of non muscle invasive urothelial bladder carcinoma. We developed a mathematical model and numerically simulated the physical processes related to this treatment. The model is based on the conductive Maxwell's equations used to simulate the therapy administration and Convection-Diffusion equation for incompressible fluid to study heat propagation through the bladder tissue. The model parameters correspond to the data provided by the thermotherapy device manufacturer. We base our computational domain on a CT image of a human bladder. Our numerical simulations can be applied to further research on the effects of chemo- thermotherapy on bladder and surrounding tissues and for treatment personalization in order to maximize the effect of the therapy while avoiding burning of the bladder. |
| format | Article |
| id | doaj-art-0581c6f140da4ea3b76c18c022ea4c18 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-0581c6f140da4ea3b76c18c022ea4c182025-01-24T02:37:49ZengAIMS PressMathematical Biosciences and Engineering1551-00182016-07-011361169118310.3934/mbe.2016037A model of thermotherapy treatment for bladder cancerChristoph Sadée0Eugene Kashdan1School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4In this work, we investigate chemo- thermotherapy, a recently clinically-approved post-surgery treatment of non muscle invasive urothelial bladder carcinoma. We developed a mathematical model and numerically simulated the physical processes related to this treatment. The model is based on the conductive Maxwell's equations used to simulate the therapy administration and Convection-Diffusion equation for incompressible fluid to study heat propagation through the bladder tissue. The model parameters correspond to the data provided by the thermotherapy device manufacturer. We base our computational domain on a CT image of a human bladder. Our numerical simulations can be applied to further research on the effects of chemo- thermotherapy on bladder and surrounding tissues and for treatment personalization in order to maximize the effect of the therapy while avoiding burning of the bladder.https://www.aimspress.com/article/doi/10.3934/mbe.2016037bladder cancerthermotherapymicrowaves. |
| spellingShingle | Christoph Sadée Eugene Kashdan A model of thermotherapy treatment for bladder cancer Mathematical Biosciences and Engineering bladder cancer thermotherapy microwaves. |
| title | A model of thermotherapy treatment for bladder cancer |
| title_full | A model of thermotherapy treatment for bladder cancer |
| title_fullStr | A model of thermotherapy treatment for bladder cancer |
| title_full_unstemmed | A model of thermotherapy treatment for bladder cancer |
| title_short | A model of thermotherapy treatment for bladder cancer |
| title_sort | model of thermotherapy treatment for bladder cancer |
| topic | bladder cancer thermotherapy microwaves. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2016037 |
| work_keys_str_mv | AT christophsadee amodelofthermotherapytreatmentforbladdercancer AT eugenekashdan amodelofthermotherapytreatmentforbladdercancer AT christophsadee modelofthermotherapytreatmentforbladdercancer AT eugenekashdan modelofthermotherapytreatmentforbladdercancer |