DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+
In this paper, three complexes of type [Co(en)2PIP]3+(PIP=2-phenylimidazo[4,5-f][1,10,] phenanthroline)(1), [Co(en)2IP]3+ (IP=imidazo[4,5-f][1,10,] phenanthroline)(2), and [Co(en)2phen-dione]3+(1,10 phenanthroline 5,6,dione)(3) have been synthesized and characterized by UV/VIS, IR, 1H NMR spectral m...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2007/54562 |
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| author | Penumaka Nagababu S. Satyanarayana |
| author_facet | Penumaka Nagababu S. Satyanarayana |
| author_sort | Penumaka Nagababu |
| collection | DOAJ |
| description | In this paper, three complexes of type [Co(en)2PIP]3+(PIP=2-phenylimidazo[4,5-f][1,10,] phenanthroline)(1), [Co(en)2IP]3+ (IP=imidazo[4,5-f][1,10,] phenanthroline)(2), and [Co(en)2phen-dione]3+(1,10 phenanthroline 5,6,dione)(3) have been synthesized and characterized by UV/VIS, IR, 1H NMR spectral methods. Absorption spectroscopy, emission spectroscopy, viscosity measurements, and DNA melting techniques have been used for investigating the binding of these two complexes with calf thymus DNA, and photocleavage studies were used for investigating these binding of these complexes with plasmid DNA. The spectroscopic studies together with viscosity measurements and DNA melting studies support that complexes 1 and 2 bind to CT DNA(=calf thymus DNA) by intercalation mode via IP or PIP into the base pairs of DNA, and complex 3 is binding as groove mode. Complex 1 binds more avidly to CT DNA than 2 and 3 which is consistent with the extended planar ring π system of PIP. Noticeably, the two complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA. |
| format | Article |
| id | doaj-art-05744645e2ae4112b9d52f84c592f864 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-05744645e2ae4112b9d52f84c592f8642025-02-03T01:30:53ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2007-01-01200710.1155/2007/5456254562DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+Penumaka Nagababu0S. Satyanarayana1Department of Chemistry, Osmania University, Hyderabad 500 007, Andhra Pradesh, IndiaDepartment of Chemistry, Osmania University, Hyderabad 500 007, Andhra Pradesh, IndiaIn this paper, three complexes of type [Co(en)2PIP]3+(PIP=2-phenylimidazo[4,5-f][1,10,] phenanthroline)(1), [Co(en)2IP]3+ (IP=imidazo[4,5-f][1,10,] phenanthroline)(2), and [Co(en)2phen-dione]3+(1,10 phenanthroline 5,6,dione)(3) have been synthesized and characterized by UV/VIS, IR, 1H NMR spectral methods. Absorption spectroscopy, emission spectroscopy, viscosity measurements, and DNA melting techniques have been used for investigating the binding of these two complexes with calf thymus DNA, and photocleavage studies were used for investigating these binding of these complexes with plasmid DNA. The spectroscopic studies together with viscosity measurements and DNA melting studies support that complexes 1 and 2 bind to CT DNA(=calf thymus DNA) by intercalation mode via IP or PIP into the base pairs of DNA, and complex 3 is binding as groove mode. Complex 1 binds more avidly to CT DNA than 2 and 3 which is consistent with the extended planar ring π system of PIP. Noticeably, the two complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA.http://dx.doi.org/10.1155/2007/54562 |
| spellingShingle | Penumaka Nagababu S. Satyanarayana DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+ Bioinorganic Chemistry and Applications |
| title | DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine
Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+ |
| title_full | DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine
Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+ |
| title_fullStr | DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine
Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+ |
| title_full_unstemmed | DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine
Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+ |
| title_short | DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine
Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+ |
| title_sort | dna binding and photocleavage studies of cobalt iii polypyridine complexes co en 2pip 3 co en 2ip 3 and co en 2phen dione 3 |
| url | http://dx.doi.org/10.1155/2007/54562 |
| work_keys_str_mv | AT penumakanagababu dnabindingandphotocleavagestudiesofcobaltiiipolypyridinecomplexescoen2pip3coen2ip3andcoen2phendione3 AT ssatyanarayana dnabindingandphotocleavagestudiesofcobaltiiipolypyridinecomplexescoen2pip3coen2ip3andcoen2phendione3 |