The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy
Decay-accelerating factor (DAF, CD55) is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. Here DAF seems to exert different functions beyond its immunological role such as e.g. promotion of tumorigenesis, decrease of complement medi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2006/814816 |
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| _version_ | 1832552337451778048 |
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| author | Jan-Henrik Mikesch Kathrin Schier Antje Roetger Ronald Simon Horst Buerger Burkhard Brandt |
| author_facet | Jan-Henrik Mikesch Kathrin Schier Antje Roetger Ronald Simon Horst Buerger Burkhard Brandt |
| author_sort | Jan-Henrik Mikesch |
| collection | DOAJ |
| description | Decay-accelerating factor (DAF, CD55) is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. Here DAF seems to exert different functions beyond its immunological role such as e.g. promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathways and specific seven-span transmembrane receptors (CD97) binding. Therefore, DAF has already become a target for therapy. In this paper we review the role of DAF in human malignancies as described in different basic, diagnostic and experimental therapeutic studies. |
| format | Article |
| id | doaj-art-056f3be651234baa885c576f3214ab2f |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-056f3be651234baa885c576f3214ab2f2025-02-03T05:58:51ZengWileyCellular Oncology1570-58701875-86062006-01-01285-622323210.1155/2006/814816The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer TherapyJan-Henrik Mikesch0Kathrin Schier1Antje Roetger2Ronald Simon3Horst Buerger4Burkhard Brandt5Department of Haematology-Oncology, University of Muenster, GermanyDepartment of Haematology-Oncology, University of Muenster, GermanyCarpegen GmbH, Muenster, GermanyInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, GermanyGerhard-Domagk-Institute of Pathology, University Hospital, Westf.-Wilhelms-Univ. Münster, GermanyTumor Biology, University Medical Centre Hamburg-Eppendorf, GermanyDecay-accelerating factor (DAF, CD55) is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. Here DAF seems to exert different functions beyond its immunological role such as e.g. promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathways and specific seven-span transmembrane receptors (CD97) binding. Therefore, DAF has already become a target for therapy. In this paper we review the role of DAF in human malignancies as described in different basic, diagnostic and experimental therapeutic studies.http://dx.doi.org/10.1155/2006/814816 |
| spellingShingle | Jan-Henrik Mikesch Kathrin Schier Antje Roetger Ronald Simon Horst Buerger Burkhard Brandt The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy Cellular Oncology |
| title | The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy |
| title_full | The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy |
| title_fullStr | The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy |
| title_full_unstemmed | The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy |
| title_short | The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy |
| title_sort | expression and action of decay accelerating factor cd55 in human malignancies and cancer therapy |
| url | http://dx.doi.org/10.1155/2006/814816 |
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