Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones
Background: Urinary stones (urolithiasis) have been categorized as kidney stones (renal calculus), ureteric stones (ureteral calculus and ureterolith), bladder stones (bladder calculus), and urethral stones (urethral calculus); however, the mechanisms underlying their promotion and related injuries...
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MDPI AG
2025-01-01
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| author | Takanobu Takata Shinya Inoue Kenshiro Kunii Togen Masauji Junji Moriya Yoshiharu Motoo Katsuhito Miyazawa |
| author_facet | Takanobu Takata Shinya Inoue Kenshiro Kunii Togen Masauji Junji Moriya Yoshiharu Motoo Katsuhito Miyazawa |
| author_sort | Takanobu Takata |
| collection | DOAJ |
| description | Background: Urinary stones (urolithiasis) have been categorized as kidney stones (renal calculus), ureteric stones (ureteral calculus and ureterolith), bladder stones (bladder calculus), and urethral stones (urethral calculus); however, the mechanisms underlying their promotion and related injuries in glomerular and tubular cells remain unclear. Although lifestyle-related diseases (LSRDs) such as hyperglycemia, type 2 diabetic mellitus, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, and cardiovascular disease are risk factors for urolithiasis, the underlying mechanisms remain unclear. Recently, heat shock protein 90 (HSP90) on the membrane of HK-2 human proximal tubular epithelium cells has been associated with the adhesion of urinary stones and cytotoxicity. Further, HSP90 in human pancreatic and breast cells can be modified by various advanced glycation end-products (AGEs), thus affecting their function. Hypothesis 1: We hypothesized that HSP90s on/in human proximal tubular epithelium cells can be modified by various types of AGEs, and that they may affect their functions and it may be a key to reveal that LSRDs are associated with urolithiasis. Hypothesis 2: We considered the possibility that Japanese traditional medicines for urolithiasis may inhibit AGE generation. Of Choreito and Urocalun (the extract of <i>Quercus salicina</i> Blume/<i>Quercus stenophylla</i> Makino) used in the clinic, Choreito is a Kampo medicine, while Urocalun is a characteristic Japanese traditional medicine. As Urocalun contains quercetin, hesperidin, and <i>p</i>-hydroxy cinnamic acid, which can inhibit AGE generation, we hypothesized that Urocalun may inhibit the generation of AGE-modified HSP90s in human proximal tubular epithelium cells. |
| format | Article |
| id | doaj-art-056c7fdac73441b0bb75a6dfe98dfc0b |
| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-056c7fdac73441b0bb75a6dfe98dfc0b2025-01-24T13:29:14ZengMDPI AGDiseases2079-97212025-01-01131710.3390/diseases13010007Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary StonesTakanobu Takata0Shinya Inoue1Kenshiro Kunii2Togen Masauji3Junji Moriya4Yoshiharu Motoo5Katsuhito Miyazawa6Division of Molecular and Genetic Biology, Department of Life Science, Medical Research Institute, Kanazawa Medical University, Uchinada 920-0293, Ishikawa, JapanDepartment of Urology, Kanazawa Medical University, Uchinada 920-0293, Ishikawa, JapanDepartment of Urology, Kanazawa Medical University, Uchinada 920-0293, Ishikawa, JapanDepartment of Pharmacy, Kanazawa Medical University Hospital, Uchinada 920-0293, Ishikawa, JapanDepartment of General Internal Medicine, Kanazawa Medical University, Uchinada 920-0293, Ishikawa, JapanDepartment of Internal Medicine, Fukui Saiseikai Hospital, Wadanaka 918-8503, Fukui, JapanDepartment of Urology, Kanazawa Medical University, Uchinada 920-0293, Ishikawa, JapanBackground: Urinary stones (urolithiasis) have been categorized as kidney stones (renal calculus), ureteric stones (ureteral calculus and ureterolith), bladder stones (bladder calculus), and urethral stones (urethral calculus); however, the mechanisms underlying their promotion and related injuries in glomerular and tubular cells remain unclear. Although lifestyle-related diseases (LSRDs) such as hyperglycemia, type 2 diabetic mellitus, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, and cardiovascular disease are risk factors for urolithiasis, the underlying mechanisms remain unclear. Recently, heat shock protein 90 (HSP90) on the membrane of HK-2 human proximal tubular epithelium cells has been associated with the adhesion of urinary stones and cytotoxicity. Further, HSP90 in human pancreatic and breast cells can be modified by various advanced glycation end-products (AGEs), thus affecting their function. Hypothesis 1: We hypothesized that HSP90s on/in human proximal tubular epithelium cells can be modified by various types of AGEs, and that they may affect their functions and it may be a key to reveal that LSRDs are associated with urolithiasis. Hypothesis 2: We considered the possibility that Japanese traditional medicines for urolithiasis may inhibit AGE generation. Of Choreito and Urocalun (the extract of <i>Quercus salicina</i> Blume/<i>Quercus stenophylla</i> Makino) used in the clinic, Choreito is a Kampo medicine, while Urocalun is a characteristic Japanese traditional medicine. As Urocalun contains quercetin, hesperidin, and <i>p</i>-hydroxy cinnamic acid, which can inhibit AGE generation, we hypothesized that Urocalun may inhibit the generation of AGE-modified HSP90s in human proximal tubular epithelium cells.https://www.mdpi.com/2079-9721/13/1/7ureteric stonelifestyle-related diseaseheat shock protein 90advanced glycation end-productsMG-H1argpyrimidine |
| spellingShingle | Takanobu Takata Shinya Inoue Kenshiro Kunii Togen Masauji Junji Moriya Yoshiharu Motoo Katsuhito Miyazawa Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones Diseases ureteric stone lifestyle-related disease heat shock protein 90 advanced glycation end-products MG-H1 argpyrimidine |
| title | Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones |
| title_full | Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones |
| title_fullStr | Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones |
| title_full_unstemmed | Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones |
| title_short | Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones |
| title_sort | advanced glycation end product modified heat shock protein 90 may be associated with urinary stones |
| topic | ureteric stone lifestyle-related disease heat shock protein 90 advanced glycation end-products MG-H1 argpyrimidine |
| url | https://www.mdpi.com/2079-9721/13/1/7 |
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