A novel sustained-release agent based on disulfide-induced recombinant collagen hydrogels for the prevention and treatment of Schistosoma infections

A novel sustained-release agent based on disulfide-induced recombinant collagen hydrogels for the prevention and treatment of Schistosoma infections

ABSTRACT Schistosomiasis is commonly managed using the praziquantel, but it is only effective against adult worms and duration of action is short. Liver fibrosis will worsen if eggs are still present after stopping treatment. Therefore, this study aimed to develop a sustained drug release system for...

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Main Authors: Jie Wang, Lijun Song, Yuntian Xing, Yang Dai, Jinyuan Hu, Guoli Qu, Yongliang Xu, Xuren Yin, Derong Hang, Jianfeng Zhang, Chunrong Xiong, Liang Shi, Fei Xu
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:Microbiology Spectrum
Subjects:
recombinant collagen hydrogel
self-assembly
praziquantel
sustained drug release
schistosomiasis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03771-23
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