Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice
Tephrosia toxicaria, which is currently known as Tephrosia sinapou (Buc’hoz) A. Chev. (Fabaceae), is a source of compounds such as flavonoids. T. sinapou has been used in Amazonian countries traditional medicine to alleviate pain and inflammation. The purpose of this study was to evaluate the analge...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/8656397 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561332845543424 |
|---|---|
| author | Renata M. Martinez Ana C. Zarpelon Talita P. Domiciano Sandra R. Georgetti Marcela M. Baracat Isabel C. Moreira Cesar C. Andrei Waldiceu A. Verri Rubia Casagrande |
| author_facet | Renata M. Martinez Ana C. Zarpelon Talita P. Domiciano Sandra R. Georgetti Marcela M. Baracat Isabel C. Moreira Cesar C. Andrei Waldiceu A. Verri Rubia Casagrande |
| author_sort | Renata M. Martinez |
| collection | DOAJ |
| description | Tephrosia toxicaria, which is currently known as Tephrosia sinapou (Buc’hoz) A. Chev. (Fabaceae), is a source of compounds such as flavonoids. T. sinapou has been used in Amazonian countries traditional medicine to alleviate pain and inflammation. The purpose of this study was to evaluate the analgesic effects of T. sinapou ethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching/licking tests. We demonstrated in this study that T. sinapou extract inhibited, in a dose (1–100 mg/kg) dependent manner, acetic acid- and phenyl-p-benzoquinone- (PBQ-) induced writhing response. Furthermore, it was active via intraperitoneal, subcutaneous, and peroral routes of administration. T. sinapou extract also inhibited formalin- and complete Freund’s adjuvant- (CFA-) induced flinching/licking at 100 mg/kg dose. In conclusion, these findings demonstrate that T. sinapou ethyl acetate extract reduces inflammatory pain in the acetic acid, PBQ, formalin, and CFA models of overt pain-like behavior. Therefore, the potential of analgesic activity of T. sinapou indicates that it deserves further investigation. |
| format | Article |
| id | doaj-art-05491fb344b14df3a311562932a0886c |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-05491fb344b14df3a311562932a0886c2025-02-03T01:25:20ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/86563978656397Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in MiceRenata M. Martinez0Ana C. Zarpelon1Talita P. Domiciano2Sandra R. Georgetti3Marcela M. Baracat4Isabel C. Moreira5Cesar C. Andrei6Waldiceu A. Verri7Rubia Casagrande8Department of Pharmaceutical Sciences, Health Science Centre, University Hospital, Londrina State University, Londrina, PR, BrazilDepartamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, BrazilDepartamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, BrazilDepartment of Pharmaceutical Sciences, Health Science Centre, University Hospital, Londrina State University, Londrina, PR, BrazilDepartment of Pharmaceutical Sciences, Health Science Centre, University Hospital, Londrina State University, Londrina, PR, BrazilUniversidade Tecnológica Federal do Paraná, Londrina, PR, BrazilLaboratório de Pesquisa em Moléculas Bioativas, Departamento de Química, Universidade Estadual de Londrina, Londrina, PR, BrazilDepartamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, BrazilDepartment of Pharmaceutical Sciences, Health Science Centre, University Hospital, Londrina State University, Londrina, PR, BrazilTephrosia toxicaria, which is currently known as Tephrosia sinapou (Buc’hoz) A. Chev. (Fabaceae), is a source of compounds such as flavonoids. T. sinapou has been used in Amazonian countries traditional medicine to alleviate pain and inflammation. The purpose of this study was to evaluate the analgesic effects of T. sinapou ethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching/licking tests. We demonstrated in this study that T. sinapou extract inhibited, in a dose (1–100 mg/kg) dependent manner, acetic acid- and phenyl-p-benzoquinone- (PBQ-) induced writhing response. Furthermore, it was active via intraperitoneal, subcutaneous, and peroral routes of administration. T. sinapou extract also inhibited formalin- and complete Freund’s adjuvant- (CFA-) induced flinching/licking at 100 mg/kg dose. In conclusion, these findings demonstrate that T. sinapou ethyl acetate extract reduces inflammatory pain in the acetic acid, PBQ, formalin, and CFA models of overt pain-like behavior. Therefore, the potential of analgesic activity of T. sinapou indicates that it deserves further investigation.http://dx.doi.org/10.1155/2016/8656397 |
| spellingShingle | Renata M. Martinez Ana C. Zarpelon Talita P. Domiciano Sandra R. Georgetti Marcela M. Baracat Isabel C. Moreira Cesar C. Andrei Waldiceu A. Verri Rubia Casagrande Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice Scientifica |
| title | Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice |
| title_full | Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice |
| title_fullStr | Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice |
| title_full_unstemmed | Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice |
| title_short | Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice |
| title_sort | antinociceptive effect of tephrosia sinapou extract in the acetic acid phenyl p benzoquinone formalin and complete freund s adjuvant models of overt pain like behavior in mice |
| url | http://dx.doi.org/10.1155/2016/8656397 |
| work_keys_str_mv | AT renatammartinez antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT anaczarpelon antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT talitapdomiciano antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT sandrargeorgetti antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT marcelambaracat antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT isabelcmoreira antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT cesarcandrei antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT waldiceuaverri antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice AT rubiacasagrande antinociceptiveeffectoftephrosiasinapouextractintheaceticacidphenylpbenzoquinoneformalinandcompletefreundsadjuvantmodelsofovertpainlikebehaviorinmice |