Antimony Resistance in Leishmania, Focusing on Experimental Research
Leishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases. There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. However, resistance toward these compounds has recent...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/695382 |
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| _version_ | 1832553444999692288 |
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| author | Fakhri Jeddi Renaud Piarroux Charles Mary |
| author_facet | Fakhri Jeddi Renaud Piarroux Charles Mary |
| author_sort | Fakhri Jeddi |
| collection | DOAJ |
| description | Leishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases. There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alternative molecules. In this paper, we reviewed the studies carried out on antimonial resistance in Leishmania. Several common limitations of these works are presented before prevalent approaches to evidence antimonial resistance are related. Afterwards, phenotypic determination of resistance is described, then confronted to clinical outcome. Finally, we detail molecular mechanisms and targets involved in resistance and already identified in vitro within selected mutant strains or in clinical isolates. |
| format | Article |
| id | doaj-art-05479db4540843b5bddd9c4740ed27d1 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-05479db4540843b5bddd9c4740ed27d12025-02-03T05:53:57ZengWileyJournal of Tropical Medicine1687-96861687-96942011-01-01201110.1155/2011/695382695382Antimony Resistance in Leishmania, Focusing on Experimental ResearchFakhri Jeddi0Renaud Piarroux1Charles Mary2Laboratoire de Parasitologie, Hôpital de la Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, FranceLaboratoire de Parasitologie, Hôpital de la Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, FranceLaboratoire de Parasitologie, Hôpital de la Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, FranceLeishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases. There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alternative molecules. In this paper, we reviewed the studies carried out on antimonial resistance in Leishmania. Several common limitations of these works are presented before prevalent approaches to evidence antimonial resistance are related. Afterwards, phenotypic determination of resistance is described, then confronted to clinical outcome. Finally, we detail molecular mechanisms and targets involved in resistance and already identified in vitro within selected mutant strains or in clinical isolates.http://dx.doi.org/10.1155/2011/695382 |
| spellingShingle | Fakhri Jeddi Renaud Piarroux Charles Mary Antimony Resistance in Leishmania, Focusing on Experimental Research Journal of Tropical Medicine |
| title | Antimony Resistance in Leishmania, Focusing on Experimental Research |
| title_full | Antimony Resistance in Leishmania, Focusing on Experimental Research |
| title_fullStr | Antimony Resistance in Leishmania, Focusing on Experimental Research |
| title_full_unstemmed | Antimony Resistance in Leishmania, Focusing on Experimental Research |
| title_short | Antimony Resistance in Leishmania, Focusing on Experimental Research |
| title_sort | antimony resistance in leishmania focusing on experimental research |
| url | http://dx.doi.org/10.1155/2011/695382 |
| work_keys_str_mv | AT fakhrijeddi antimonyresistanceinleishmaniafocusingonexperimentalresearch AT renaudpiarroux antimonyresistanceinleishmaniafocusingonexperimentalresearch AT charlesmary antimonyresistanceinleishmaniafocusingonexperimentalresearch |