Management of Hepatic Encephalopathy

Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of int...

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Main Authors: G. Wright, A. Chattree, R. Jalan
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.4061/2011/841407
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author G. Wright
A. Chattree
R. Jalan
author_facet G. Wright
A. Chattree
R. Jalan
author_sort G. Wright
collection DOAJ
description Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease.
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institution Kabale University
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spelling doaj-art-0542af3d50ec4fb78857c878488461c22025-02-03T06:11:16ZengWileyInternational Journal of Hepatology2090-34482090-34562011-01-01201110.4061/2011/841407841407Management of Hepatic EncephalopathyG. Wright0A. Chattree1R. Jalan2University College London Institute of Hepatology, The Royal Free Hospital, Pond Street, London NW3 2PF, UKDepartment of Gastroenterology, King Georges Hospital, Barley Lane, Goodmayes, Ilford, Essex IG3 8YB, UKUniversity College London Institute of Hepatology, The Royal Free Hospital, Pond Street, London NW3 2PF, UKHepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease.http://dx.doi.org/10.4061/2011/841407
spellingShingle G. Wright
A. Chattree
R. Jalan
Management of Hepatic Encephalopathy
International Journal of Hepatology
title Management of Hepatic Encephalopathy
title_full Management of Hepatic Encephalopathy
title_fullStr Management of Hepatic Encephalopathy
title_full_unstemmed Management of Hepatic Encephalopathy
title_short Management of Hepatic Encephalopathy
title_sort management of hepatic encephalopathy
url http://dx.doi.org/10.4061/2011/841407
work_keys_str_mv AT gwright managementofhepaticencephalopathy
AT achattree managementofhepaticencephalopathy
AT rjalan managementofhepaticencephalopathy