Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer
It has been revealed that certain organochlorine pesticides may increase the risk of gastric cancer incidence among farm workers. This research aimed to assay levels of 7 different organochlorine pesticides in the serum of functional dyspepsia, intestinal metaplasia and gastric cancer patients, alon...
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Elsevier
2025-01-01
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| author | Gholamreza Asadikaram Mohammad Reza Ashrafi Sodaif Darvish Moghaddam Moslem Abolhassani Fatemeh Bagheri |
| author_facet | Gholamreza Asadikaram Mohammad Reza Ashrafi Sodaif Darvish Moghaddam Moslem Abolhassani Fatemeh Bagheri |
| author_sort | Gholamreza Asadikaram |
| collection | DOAJ |
| description | It has been revealed that certain organochlorine pesticides may increase the risk of gastric cancer incidence among farm workers. This research aimed to assay levels of 7 different organochlorine pesticides in the serum of functional dyspepsia, intestinal metaplasia and gastric cancer patients, along with measuring oxidative stress parameters compared to the control group and their associations. The levels of organochlorine pesticides in the serum of gastric cancer (n = 34), intestinal metaplasia (n = 8), functional dyspepsia patients (n = 48) and control group (n = 46), were measured by gas chromatography equipment. Oxidative stress parameters and erythrocyte acetylcholine esterase activity were also measured in these individuals. The levels of some organochlorine pesticides in the serum of gastric cancer patients were significantly higher than those in the control group. Moreover, the profiles of organochlorine pesticide concentrations were different in gastric cancer, intestinal metaplasia and functional dyspepsia patients. Overall, oxidant parameters were significantly higher in gastric cancer and intestinal metaplasia patients than those in functional dyspepsia patients and the control group, except in the case of malondialdehyde. The antioxidant and acetylcholine esterase enzyme activities were significantly higher in the control group than in other groups. Our results showed that progression from functional dyspepsia towards intestinal metaplasia and gastric cancer was associated with elevations in organochlorine pesticide serum levels, which had an association with the induction of oxidative stress and the reduction of antioxidant and acetylcholine esterase enzyme activities. |
| format | Article |
| id | doaj-art-052c76bfe27947d8aa76ffaf8162df2a |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| spelling | doaj-art-052c76bfe27947d8aa76ffaf8162df2a2025-02-02T05:27:52ZengElsevierHeliyon2405-84402025-01-01112e41599Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancerGholamreza Asadikaram0Mohammad Reza Ashrafi1Sodaif Darvish Moghaddam2Moslem Abolhassani3Fatemeh Bagheri4Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Department of Clinical Biochemistry, Afzalipur School of Medicine, Kerman University of Medical Sciences, Kerman, IranApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Department of Clinical Biochemistry, Afzalipur School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Corresponding author. Department of clinical Biochemistry, Afzalipur School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, IranApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, IranPathology and Stem Cell Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, IranIt has been revealed that certain organochlorine pesticides may increase the risk of gastric cancer incidence among farm workers. This research aimed to assay levels of 7 different organochlorine pesticides in the serum of functional dyspepsia, intestinal metaplasia and gastric cancer patients, along with measuring oxidative stress parameters compared to the control group and their associations. The levels of organochlorine pesticides in the serum of gastric cancer (n = 34), intestinal metaplasia (n = 8), functional dyspepsia patients (n = 48) and control group (n = 46), were measured by gas chromatography equipment. Oxidative stress parameters and erythrocyte acetylcholine esterase activity were also measured in these individuals. The levels of some organochlorine pesticides in the serum of gastric cancer patients were significantly higher than those in the control group. Moreover, the profiles of organochlorine pesticide concentrations were different in gastric cancer, intestinal metaplasia and functional dyspepsia patients. Overall, oxidant parameters were significantly higher in gastric cancer and intestinal metaplasia patients than those in functional dyspepsia patients and the control group, except in the case of malondialdehyde. The antioxidant and acetylcholine esterase enzyme activities were significantly higher in the control group than in other groups. Our results showed that progression from functional dyspepsia towards intestinal metaplasia and gastric cancer was associated with elevations in organochlorine pesticide serum levels, which had an association with the induction of oxidative stress and the reduction of antioxidant and acetylcholine esterase enzyme activities.http://www.sciencedirect.com/science/article/pii/S240584402417630XOrganochlorine pesticidesOxidative stressGastric cancerIntestinal metaplasiaFunctional dyspepsia |
| spellingShingle | Gholamreza Asadikaram Mohammad Reza Ashrafi Sodaif Darvish Moghaddam Moslem Abolhassani Fatemeh Bagheri Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer Heliyon Organochlorine pesticides Oxidative stress Gastric cancer Intestinal metaplasia Functional dyspepsia |
| title | Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer |
| title_full | Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer |
| title_fullStr | Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer |
| title_full_unstemmed | Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer |
| title_short | Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer |
| title_sort | association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer |
| topic | Organochlorine pesticides Oxidative stress Gastric cancer Intestinal metaplasia Functional dyspepsia |
| url | http://www.sciencedirect.com/science/article/pii/S240584402417630X |
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