Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study
<b>Background/Objectives</b>: Prolonged prelabour rupture of membranes (PROMs), and the resulting inflammatory response, can contribute to the occurrence of adverse neonatal outcomes, especially for early-preterm neonates. This prospective study aimed to measure neonates’ inflammatory ma...
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MDPI AG
2025-01-01
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| author | Maura-Adelina Hincu Liliana Gheorghe Luminita Paduraru Daniela-Cristina Dimitriu Anamaria Harabor Ingrid-Andrada Vasilache Iustina Solomon-Condriuc Alexandru Carauleanu Ioana Sadiye Scripcariu Dragos Nemescu |
| author_facet | Maura-Adelina Hincu Liliana Gheorghe Luminita Paduraru Daniela-Cristina Dimitriu Anamaria Harabor Ingrid-Andrada Vasilache Iustina Solomon-Condriuc Alexandru Carauleanu Ioana Sadiye Scripcariu Dragos Nemescu |
| author_sort | Maura-Adelina Hincu |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Prolonged prelabour rupture of membranes (PROMs), and the resulting inflammatory response, can contribute to the occurrence of adverse neonatal outcomes, especially for early-preterm neonates. This prospective study aimed to measure neonates’ inflammatory markers in the first 72 h of life based on ROM duration. The second aim was to examine the relationship between PROMs, serum inflammatory markers, and composite adverse neonatal outcomes after controlling for gestational age (GA). <b>Methods</b>: Data from 1026 patients were analyzed considering the following groups: group 1 (ROM < 18 h, <i>n</i> = 447 patients) and group 2 (ROM > 18 h, <i>n</i> = 579 patients). These groups were further segregated depending on the GA at the moment of membranes’ rupture into subgroup 1 (<33 weeks of gestation and 6 days, <i>n</i> = 168 patients) and subgroup 2 (at least 34 completed weeks of gestation, <i>n</i> = 858 patients). Multiple logistic regressions and interaction analyses adjusted for GA considering five composite adverse neonatal outcomes and predictors were employed. <b>Results</b>: PROMs and high c-reactive protein (CRP) values significantly increased the risk of composite outcome 1 occurrence by 14% (95%CI: 1.03–1.57, <i>p</i> < 0.001). PROMs and high CRP values increased the risk of composite outcome 5 by 14% (95%CI: 1.07–1.78, <i>p</i> < 0.001), PROM and leukocytosis by 11% (95%CI: 1.02–1.59, <i>p</i> = 0.001), and PROMs and high PCT values by 21% (95%CI: 1.04–2.10, <i>p</i> < 0.001). <b>Conclusions</b>: The combination of PROMs and high CRP values significantly increased the risk of all evaluated adverse composite outcomes in early-preterm neonates and should point to careful monitoring of these patients. |
| format | Article |
| id | doaj-art-0526f42fc58a48daa898826cbf5a9441 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-0526f42fc58a48daa898826cbf5a94412025-01-24T13:29:08ZengMDPI AGDiagnostics2075-44182025-01-0115221310.3390/diagnostics15020213Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective StudyMaura-Adelina Hincu0Liliana Gheorghe1Luminita Paduraru2Daniela-Cristina Dimitriu3Anamaria Harabor4Ingrid-Andrada Vasilache5Iustina Solomon-Condriuc6Alexandru Carauleanu7Ioana Sadiye Scripcariu8Dragos Nemescu9Department of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaSurgical Department, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Morpho-Functional Sciences II, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaClinical and Surgical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800216 Galati, RomaniaDepartment of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Mother and Child Care, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, Romania<b>Background/Objectives</b>: Prolonged prelabour rupture of membranes (PROMs), and the resulting inflammatory response, can contribute to the occurrence of adverse neonatal outcomes, especially for early-preterm neonates. This prospective study aimed to measure neonates’ inflammatory markers in the first 72 h of life based on ROM duration. The second aim was to examine the relationship between PROMs, serum inflammatory markers, and composite adverse neonatal outcomes after controlling for gestational age (GA). <b>Methods</b>: Data from 1026 patients were analyzed considering the following groups: group 1 (ROM < 18 h, <i>n</i> = 447 patients) and group 2 (ROM > 18 h, <i>n</i> = 579 patients). These groups were further segregated depending on the GA at the moment of membranes’ rupture into subgroup 1 (<33 weeks of gestation and 6 days, <i>n</i> = 168 patients) and subgroup 2 (at least 34 completed weeks of gestation, <i>n</i> = 858 patients). Multiple logistic regressions and interaction analyses adjusted for GA considering five composite adverse neonatal outcomes and predictors were employed. <b>Results</b>: PROMs and high c-reactive protein (CRP) values significantly increased the risk of composite outcome 1 occurrence by 14% (95%CI: 1.03–1.57, <i>p</i> < 0.001). PROMs and high CRP values increased the risk of composite outcome 5 by 14% (95%CI: 1.07–1.78, <i>p</i> < 0.001), PROM and leukocytosis by 11% (95%CI: 1.02–1.59, <i>p</i> = 0.001), and PROMs and high PCT values by 21% (95%CI: 1.04–2.10, <i>p</i> < 0.001). <b>Conclusions</b>: The combination of PROMs and high CRP values significantly increased the risk of all evaluated adverse composite outcomes in early-preterm neonates and should point to careful monitoring of these patients.https://www.mdpi.com/2075-4418/15/2/213prolonged rupture of membranesinflammatory markersadverse composite outcomesearly-preterm neonates |
| spellingShingle | Maura-Adelina Hincu Liliana Gheorghe Luminita Paduraru Daniela-Cristina Dimitriu Anamaria Harabor Ingrid-Andrada Vasilache Iustina Solomon-Condriuc Alexandru Carauleanu Ioana Sadiye Scripcariu Dragos Nemescu Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study Diagnostics prolonged rupture of membranes inflammatory markers adverse composite outcomes early-preterm neonates |
| title | Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study |
| title_full | Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study |
| title_fullStr | Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study |
| title_full_unstemmed | Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study |
| title_short | Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study |
| title_sort | impact of extended membrane rupture on neonatal inflammatory responses and composite neonatal outcomes in early preterm neonates a prospective study |
| topic | prolonged rupture of membranes inflammatory markers adverse composite outcomes early-preterm neonates |
| url | https://www.mdpi.com/2075-4418/15/2/213 |
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